Consortium employees are marked in bold. The posts are sorted chronologically.

2022

  • Kaplonek P, Yao L, Reppe K, Voß F, Kohler T, Ebner F, Schäfer A, Blohm U, Priegue P, Bräutigam M, Pereira CL, Parameswarappa SG, Emmadi M, Ménová P, Witzenrath M, Hammerschmidt S, Hartmann S, Sander LE, Seeberger PH. A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae, Vaccine in press https://doi.org/10.1016/j.vaccine.2021.12.068

  • Paulikat AD, Tölken LE, Jachmann LH, Burchhardt G, Hammerschmidt S, Siemens N. 2022. Streptococcus pneumoniae Impairs Maturation of Human Dendritic Cells and Consequent Activation of CD4+ T Cells via Pneumolysin. J Innate Immun. 2022 Mar 4;1-12.  doi: 10.1159/000522339 Online ahead of print.

  • Schultz D, Cuypers F, Skorka SB, Rockstroh J, Gesell Salazar M, Krieger J, Albrecht D, Völker U, Hammerschmidt S, Lalk M, Siemens N, Methling K, 2022. Bioactive lipid screening during respiratory tract infections with bacterial and viral pathogens in mice. Metabolomics. 2022 Jun 10;18(6):39. doi: 10.1007/s11306-022-01898-4.
  • Sura T, Gering V, Cammann C, Hammerschmidt S, Maaß S, Seifert U, Becher D. 2022. Streptococcus pneumoniae and Influenza A Virus Co-Infection Induces Altered Polyubiquitination in A549 Cells. Front Cell Infect Microbiol. 2022 Feb 24;12:817532. doi: 10.3389/fcimb.2022.817532. eCollection 2022.

2021

  • Abdullah MR, Batuecas MT, Jennert F, Voß F, Westhoff P, Kohler TP, Molina R, Hirschmann S, Lalk M, Hermoso JA, Hammerschmidt S. Crystal Structure and Pathophysiological Role of the Pneumococcal Nucleoside-binding Protein PnrA, Journal of Molecular Biology Volume 433, Issue 2, 22 January 2021, 166723. https://doi.org/10.1016/j.jmb.2020.11.022

  • Ali MQ, Kohler TP Burchhardt G, Wüst A, Henck N, Bolsmann R, Voß F, Hammerschmidt S. Extracellular Pneumococcal Serine Proteases Affect Nasopharyngeal Colonization. Front. Cell. Infect. Microbiol., 15 February 2021 | https://doi.org/10.3389/fcimb.2020.613467

  • Cuypers F, Schäfer A, Skorka SB, Surabhi S, Tölken LA, Paulikat AD, Kohler TP, Otto SA, Mettenleiter TC, Hammerschmidt S, Blohm U, Siemens N. Innate immune responses at the asymptomatic stage of influenza A viral infections of Streptococcus pneumoniae colonized and non-colonized mice. Scientific Reports 11, Article number: 20609 (2021). https://doi.org/10.1038/s41598-021-00211-y

  • Gierse LC, Meene A, Schultz D, Schwaiger T, Schröder C, Mücke P, Zühlke D, Hinzke T, Wang H, Methling K, Kreikemeyer B, Bernhardt J, Becher A, Mettenleiter TC, Lalk M, Urich T, Riedel K. Influenza A H1N1 Induced Disturbance of the Respiratory and Fecal Microbiome of German Landrace Pigs – a Multi-Omics Characterization. Microbiol Spectr 9:e00182-21. https://doi.org/10.1128/Spectrum .00182-21.

  • Schulz A, Methling K, Lalk M, Eisenbarth A, Keller M, Groschup MH. Ethanol inactivation of orthonairoviruses in ixodid ticks. Experimental and Applied Acarology (2021) 85:75–81 https://doi.org/10.1007/s10493-021-00656-w

  • Surabhi S, Jachmann LH, Lalk M, Hammerschmidt S, Methling K, Siemens N. Bronchial Epithelial Cells Accumulate Citrate Intracellularly in Response to Pneumococcal Hydrogen Peroxide. ACS Infect. Disease 2021 https://doi.org/10.1021/acsinfecdis.1c00372

  • Surabhi S, Jachmann LH, Shumba P, Burchhardt G, Hammerschmidt S, Siemens N. Hydrogen Peroxide Is Crucial for NLRP3
    Inflammasome-Mediated IL-1β Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells. J Innate Immun. DOI: 10.1159/000517855

  • Volzke J, Müller-Hilke B. Degenerative Joint Damage Is Not a Risk Factor for Streptococcal Sepsis and Septic Arthritis in Mice. Life 2021, 11, 794. https://doi.org/10.3390/life11080794

  • Zaeck LM, Scheibner D, Sehl J, Müller M, Hoffmann D, Beer M, Abdelwhab EM, Mettenleiter TC, Breithaupt A, Finke S. Light Sheet Microscopy-Assisted 3D Analysis of SARS-CoV-2 Infection in the Respiratory Tract of the Ferret Model. Viruses 2021 Mar 23;13(3):529. doi: 10.3390/v13030529. 

2020

  • Barkowsky G, Kreikemeyer B, Patenge N. Validation of Suitable Carrier Molecules and Target Genes for Antisense Therapy Using Peptide-Coupled Peptide Nucleic Acids (PNAs) in Streptococci. Proft T., Loh J. (eds) Group A Streptococcus. Methods in Molecular Biology, vol 2136. Humana, New York, NY 2020 https://doi.org/10.1007/978-1-0716-0467-0_27

  • Cuypers F, Klabunde B, Gesell Salazar M, Surabhi S, Skorka SB, Burchhardt G, Michalik S, Thiele T, Rohde M, Völker U, Hammerschmidt S, Siemens N. Adenosine Triphosphate Neutralizes Pneumolysin-induced Neutrophil Activation. J Infect Dis 2020 May 23;jiaa277. doi: 10.1093/infdis/jiaa277. PubMed

  • Gierse LC, Meene A, Schultz D, Schwaiger T, Karte C, Schröder C, Wang H, Wünsche C, Methling K, Kreikemeyer B, Fuchs S, Bernhardt J, Becher D, Lalk M, KoInfekt Study Group, Urich T, Riedel K. A Multi-Omics Protocol for Swine Feces to Elucidate Longitudinal Dynamics in Microbiome Structure and Function. Microorganisms 2020, 8, 1887. doi:10.3390/microorganisms8121887

  • Haralambiev L, Bandyophadyay A, Suchy B, Weiss M, Kramer A, Bekeschuss S, Ekkernkamp A, Mustea A, Kaderali L, Stope MB. Determination of Immediate vs Kinetic Growth Retardateion in Physically Plasma-treated Cells by Experimental and Modelling Data. Anticancer Res 2020 Jul; 40(7):3743-3749. 10.21873/anticanres.14363 PubMed

  • Karte C, Platje N, Bullermann J, Beer M, Höper D, Blome S. Re-emergence of porcine epidemic diarrhea virus in a piglet-producing farm in  northwestern Germany in 2019. BMC Veterinary Research (2020) 16:329 https://doi.org/10.1186/s12917-020-02548-4

  • KöhlerJ, Ehler J, Kreikemeyer B, Bajorath R, Schürholz T, Oehmcke-Hecht S. The synthetic LPS binding peptide 19-2.5 interferes with clotting and prevents degradation of high molecular weight kininogen in plasma. Sci Rep 2020 Apr 28;10(1):7142. doi: 10.1038/s41598-020-64155-5. PubMed

  • Köhler J, Maletzki C, Koczan D, Frank M, Springer A, Steffen C, Revenko AS, MacLeod AR, Mikkat S, Kreikemeyer B, Oehmcke-Hecht S. Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis. EBioMedicine 2020 Aug;58:102908. doi: 10.1016/j.ebiom.2020.102908. Epub 2020 Jul 21

  • Leonard A, Möhlis K, Schlüter R, Taylor E, Lalk M, Methling K. Exploring metabolic adaptation of Streptococcus pneumoniae to antibiotics. The Journal of Antibiotics volume 73, pages441–454(2020). PubMed

  • Matthiesen S, ZaeckL, Franzke K, Jahnke R, Fricke C, Mauermeir M, Finke S, Lührmann A, KnittlerMR. Coxiella burnetii-infected NK cells release infectious bacteria by degranulation. Infect Immun IAI.00172-20. doi: 10.1128/IAI.00172-20. Online ahead of print. PubMed

  • Oehmcke-Hecht S, Mandl V, Naatz LT, Dühring L, Köhler J, Kreikemeyer B, Maletzki C. Streptococcus gallolyticus abrogates anti-carcinogenic properties of tannic acid on low-passage colorectal carcinomas. Sci Rep. 2020 Mar 13;10(1):4714. doi: 10.1038/s41598-020-61458-5.

  • Potratz M, Zaeck L, Christen M, Te Kamp V, Klein A, Nolden T, Freuling CM, Müller T, Finke S. Astrocyte Infection during Rabies Encephalitis Depends on the Virus Strain and Infection Route as Demonstrated by Novel Quantitative 3D Analysis of Cell Tropism. Cells 11;9(2). pii: E412. doi: 10.3390/cells9020412. MDPI

  • Potratz M, Zaeck LM, Weigel C, Klein A, Freuling CM, Müller T, Finke S. Neuroglia infection by rabies virus after anterograde virus spread in peripheral neurons. Acta Neuropathol Commun 2020 Nov 23;8(1):199.  doi: 10.1186/s40478-020-01074-6. PubMed

  • Schultz D, Surabhi S, Stelling N, Rothe M, KoInfekt Study Group, Methling K, Hammerschmidt S, Siemens N, Lalk M. 16HBE Cell Lipid Mediator Responses to Mono and Co-Infections with Respiratory Pathogens. Metabolites 2020, 10(3), 113; doi.org/10.3390/metabo10030113. PubMed

  • Schweinoch D, Bachmann P, Clausznitzer D, Binder M, Kaderali  L. Mechanistic modeling explains the dsRNA lengthdependent activation of the RIG-I mediated immune response. J Theor Biol 2020 Sep 7;500:110336.  doi: 10.1016/j.jtbi.2020.110336. PubMed

  • Siemens N, Snäll J, Svensson M, Norrby-Teglund A. Pathogenic Mechanisms of Streptococcal Necrotizing Soft Tissue Infections. Adv Exp Med Biol. 2020;1294:127-150. doi: 10.1007/978-3-030-57616-5_9. PubMed

  • Surabhi S, Cuyper F, Hammerschmidt S, Siemens N. The Role of NLRP3 Inflammasome in Pneumococcal Infections.
    Front Immunol. 2020 Dec 14;11:614801. doi: 10.3389/fimmu.2020.614801. eCollection 2020. PubMed

  • Volzke J, Schultz D, Kordt M, Müller M, Bergmann W, Methling K, Kreikemeyer B, Müller-Hilke B, KoInfekt Study Group. Inflammatory Joint Disease Is a Risk Factor for Streptococcal Sepsis and Septic Arthritis in Mice. Front. Immunol., 07 October 2020 doi: 10.3389/fimmu.2020.579475 Frontiers

  • Voß F, van Beek LF, Schwudke D, Ederveen THA, van Opzeeland FJ, Thalheim D, Werner S, de Jonge MI, Hammerschmidt S. Lipidation of Pneumococcal Antigens Leads to Improved Immunogenicity and Protection. Vaccines (Basel) 2020 Jun 17;8(2):E310. doi: 10.3390/vaccines8020310. PubMed

Publications

2019

  • Barkowsky G, Lemster A-L, Pappesch R, Jacob A, Krüger S, Schröder A, Kreikemeyer B, Patenge N. Influence of different Cell-Penetrating Peptides on the antimicrobial efficiency of antisense Peptide Nucleic Acids in Streptococcus pyogenes. Mol.Ther.Nucleic Acids. 2019 Dec 6; 18: 444–454. doi: 10.1016/j.omtn.2019.09.010. PubMed

  • Köhler J, Maletzki C, Koczan D, Frank M, Trepesch C, Revenko AS, Crosby JR, MacLeod AR, Mikkat S, Oehmcke-Hecht S. The contact system proteases play disparate roles in streptococcal sepsis. Haematologica. 2019 Jul 18. pii: haematol.2019.223545. doi: 10.3324/haematol.2019.223545. PubMed

  • Schäfer A, Hühr J, Schwaiger T, Dorhoi A, Mettenleiter TC, Blome S, Schröder C, Blohm U. Porcine Invariant Natural Killer T Cells: Functional Profiling and Dynamics in Steady State and Viral Infections. Front Immunol. 2019 Jun 18;10:1380. doi: 10.3389/fimmu.2019.01380. eCollection 2019. PubMed

  • Schultz D, Methling K, KoInfekt Study Group, Rothe M, Lalk M. Eicosanoid Profile of Influenza A Virus Infected Pigs. Metabolites. 2019 Jul 3;9(7). pii: E130. doi: 10.3390/metabo9070130. PubMed

  • Schwaiger T, Sehl J, Karte C, Schäfer A, Hühr J, Mettenleiter TC, Schröder C, Köllner B, Ulrich R, Blohm U. Experimental H1N1pdm09 infection in pigs mimics human seasonal influenza infections. PLOS ONE 2019, 14 (9), e0222943. PubMed
  • Shumba P, Mairpady Shambat S, Siemens N. The role of streptococcal and staphylococcal exotoxins and proteases in human necrotizing soft tissue infections. Toxins (Basel). 2019 Jun 11;11(6). pii: E332. doi: 10.3390/toxins11060332. PubMed
  • Siemens N, Oehmcke-Hecht S, Hoßmann J, Skorka SB, Nijhuis RHT, Ruppen C, Skrede S, Rohde M, Schultz D, Lalk M, Itzek A, Pieper DH, van den Bout CJ, Claas ECJ, Kuijper EJ, Mauritz R, Sendi P, Wunderink HF, Norrby-Teglund A. Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment. J Innate Immun. 2019 Nov 19:1-13. doi: 10.1159/000504002. PubMed
  • Söllinger A, Urich T*. Methylotrophic methanogens everywhere - physiology and ecology of novel players in global methane cycling. Biochemical Society Transactions 2019 47 (6), 1895-1907. PubMed
  • Traxler S, Barkowsky G, Saß R, Klemenz A-C, Patenge N, Kreikemeyer B, Schubert JK, Miekisch W. Volatile scents of influenza A and S. pyogenes (co-)infected cells. Sci Rep 2019 Dec 11;9(1):18894. PubMed
  • Zaeck L, Potratz M, Freuling CM, Müller T, Finke S.  High-Resolution 3D Imaging of Rabies Virus Infection in Solvent-Cleared BrainTissue. Journal of Visualized Experiments (146), e59402, doi:10.3791/59402 (2019). JoVe video

2018

  • Darisipudi MN, Nordengrün M, Bröker BM, Péton V. Messing with the Sentinels - The Interaction of Staphylococcus aureus with Dendritic Cells. Microorganisms  6 (3): 87 (2018). PubMed
  • Hoyer J, Bartel J, Gómez-Mejia A, Rohde M, Hirschfeld C, Heß N, Sura T, Maaß S, Hammerschmidt S, Becher D. Proteomic response of Streptococcus pneumoniae to iron limitation. Int J Med Microbiol 2018; pii: S1438-4221(17)30471-X. doi: 10.1016/j.ijmm.2018.02.001. [Epub ahead of print] PubMed
  • Jarick M, Bertsche U, Stahl M, Schultz D, Methling K, Lalk M, Stigloher C, Steger M, Schlosser A, Ohlsen K. The serine/threonine kinase Stk and the phosphatase Stp regulate cell wall synthesis in Staphylococcus aureus. Sci Rep 2018; 8(1):13693. doi: 10.1038/s41598-018-32109-7. PubMed
  • Khani A, Popp N, Kreikemeyer B, Patenge N. A Glycine Riboswitch in Streptococcus pyogenes controls Expression of a Sodium: Alanine Symporter Family Protein Gene. Front Microbiol 2018; 9:200. Frontiers 
  • Nordengrün M, Michalik S, Völker U, Bröker BM, Gómez-Gascón L. The quest for bacterial allergens. International Journal of Medical Microbiology 308 (6): 738-750 (2018). PubMed
  • Oehmcke-Hecht S, Köhler J. Interaction of the human contact system with pathogens - an update. Front Immunol 2018; 9:312. Frontiers

  • Traxler S, Bischoff A-C, Saß R, Trefz P, Gierschner P, Brock B, Schwaiger T, Karte C, Blohm U,  Schröder C, Miekisch W, Schubert JK. VOC breath profile in spontaneously breathing awake swine during Influenza A infection. Scientific Reports 8 (1): 14857 (2018). PubMed

  • Traxler S, Bischoff A-C, Trefz P, Schubert JK, Miekisch W. Versatile set-up for non-invasive in vitro analysis of headspace VOCs. J Breath Res 2018;12(4):041001. doi: 10.1088/1752-7163/aaccad. PubMed

2017

  • Siemens N, Oehmcke-Hecht S, Mettenleiter TC, Kreikemeyer B, Valentin-Weigand P, Hammerschmidt S. Port d'Entrée for Respiratory Infections - Does the Influenza A Virus Pave the Way for Bacteria? Front Microbiol 2017; 8:2602. PubMed