Publications

Publications   Reviews   Book Chapter    Books

2024

  • Fritsch KJ, Krüger L, Handtke S, Kohler TP, Ozhiganova A, Jahn K, Wesche J, Greinacher A, Hammerschmidt S. Pneumococcal Neuraminidases Increase Platelet Killing by Pneumolysin. 
    Thrombosis and Haemostasis Aug 2024 doi: 10.1055/a-2369-8680
  • Brendel M, Kohler TP, Neufend JV, Puppe A, Gisch N, Hammerschmidt S. lipoteichoic acids are essential for pneumococcal colonization and membrane integrity. Journal of Innate Immunity 2024 Jun 20. doi: 10.1159/000539934
  • Alcorlo M, Abdullah MR, Steil L, Sotomayor F, López-de Oro L, de Castro S, Velázquez S, Kohler TP, Jiménez E, Medina A, Usón I, Keller LE, Bradshaw JL, McDaniel LS, Camarasa MJ, Völker U, Hammerschmidt S, Hermoso JA. Molecular and structural basis of oligopeptide recognition by the Ami transporter system in pneumococci. PLOS Pathogens 2024 Jun 05. doi: 10.1371/journal.ppat.1011883
  • Purwanto DS, Khoeri MM, Tafroji W, Margaretha Kaligis SH, Wilar R, Johnson Kepel B, Raranta HPT, Gaghiwu L, Hammerschmidt S, Ervina WF, Safari D. Nasopharyngeal carriage rate, serotype distribution, and antimicrobial profiles of Streptococcus pneumoniae among patients with acute respiratory tract infection in Manado, North Sulawesi, Indonesia. Acces Microbiology 2024 Mar 15. doi: 10.1099/acmi.0.000703.v4
  • Paulikat AD, Schwudke D, Hammerschmidt S, Voß F. Lipidation of pneumococcal proteins enables activation of human antigen-presenting cells and initiation of an adaptive immune response. Frontiers 2024 Apr 22. doi: 10.3389/fimmu.2024.1392316 
  • He SWJ, Voß F, Nicolaie MA, Brummelman J, van de Garde MDB, Bijvank E, Poelen M, Wijmenga-Monsuur AJ, Wyllie AL, Trzciński K, Van Beek J, Rots NY, den Hartog G, Hammerschmidt S, van Els CACM. Serological profiling of pneumococcal proteins reveals unique patterns of acquisition, maintenance and waning of antibodies throughout life. J Infect Dis. 2024 Apr 29. doi: 10.1093/infdis/jiae216
  • Serra S, Iannotti V, Ferrante M, Tofiño-Vian M, Baxendale J, Silberberg G, Kohler TP, Hammerschmidt S, Ulijasz AT, Iovino F. 2024. The single D380 amino acid substitution increases pneumolysin cytotoxicity toward neuronal cells. Science. 2024 Mar 27. doi: 10.1016/j.isci.2024.109583
  • Jennert F, Schaaf D, Nau R, Kohler TP, Hammerschmidt S, Häusler D, Valentin-Weigand P, Seele J. 2024. Hydrogen peroxide is responsible for the cytotoxic effects of Streptococcus pneumoniae on primary microglia in the absence of pneumolysin. Journal of Innate Immunity. 2024 Apr 3. doi: 10.1159/000536514
  • Dyckhoff-Shen S, Masouris I, Islam H, Hammerschmidt S, Angele B, Marathe V, Buer J, Völk S, Pfister HW, Klein M, Koedel U, Kirschning CJ. 2024. Combining antibiotic with anti-TLR2/TLR13 therapy prevents brain pathology in pneumococcal meningitis. JCI Insight. 2024 Feb 15. doi: 10.1172/jci.insight.165737
  • Gonzalez JJI, Hossain MF, Neef J, Zwack EE, Tsai C-M, Raafat D, Fechtner K, Herzog L, Kohler TP, Schlüter R, Reder A, Holtfreter S, Liu GY, Hammerschmidt S, Völker U, Torres VJ, van Dijl JM, Lillig CH, Bröker BM, Darisipudi MN.. 2024. TLR4 sensing of IsdB of Staphylococcus aureus induces a proinflammatory cytokine response via the NLRP3-caspase-1 inflammasome cascade. ASM Journals. 2024 Jan 16. doi: 10.1128/mbio.00225-23

2023

  • Teske NC, Dyckhoff-Shen S, Beckenbauer P, Bewersdorf JP, Engelen-Lee JY, Hammerschmidt S, Kälin RE, Pfister HW, Brouwer MC, Klein M, Glass R, van de Beek D, Koedel U. 2023. Pericytes are protective in experimental pneumococcal meningitis through regulating leukocyte infiltration and blood-brain barrier function. Journal of Neuroinflammation 2023 Nov 17. doi: 10.1186/s12974-023-02938-z
  • Lapschies AM, Aubry E, Kohler TP, Goldmann O, Hammerschmidt S, Nerlich A, Eichhorn I, van Vorst K, Fulde M. 2023. The type-2 Streptococcus canis M protein SCM-2 binds fibrinogen and facilitates antiphagocytic properties. Frontiers 2023 Oct 26. doi: 10.3389/fmicb.2023.1228472
  • Klabunde B, Wesener A, Bertrams W, Beinborn I, Paczia N, Surmann K, Blankenburg S, Wilhelm J, Serrania J, Knoops K, Elsayed EM, Laakmann K, Jung AL, Kirschbaum A, Hammerschmidt S, Alshaar B, Gisch N, Abu Mraheil M, Becker A, Völker U, Vollmeister E, Benedikter BJ, Schmeck B. 2023. NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections. 2023. Nature Communications. 2023 Oct 2. doi: 10.1038/s41467-023-41372-w
  • Vilhena C, Du S, Battista M, Westermann M, Kohler T, Hammerschmidt S, Zipfel PF. 2023. The choline-binding proteins PspA, PspC, and LytA of Streptococcus pneumoniae and their interaction with human endothelial and red blood cells. 2023. ASM Journals 2023 Sep 14. doi: 10.1128/iai.00154-23
  • Battista M, Hoffmann B, Bachelot Y, Zimmermann L, Teuber L, Jost A, Linde S, Westermann M, Müller MM, Slevogt H, Hammerschmidt S, Figge MT, Vilhena C, Zipfel PF. 2023. The role of pneumococcal extracellular vesicles on the pathophysiology of the kidney disease hemolytic uremic syndrome. mSphere. 2023 Jun 26. doi: 10.1128/msphere.00142-23
  • Gierse LC, Meene A, Skorka S, Cuypers F, Surabhi S, Ferrero-Bordera B, Kreikemeyer B, Becher D, Hammerschmidt S, Siemens N, Urich T, Riedel K., 2023. Impact of Pneumococcal and Viral Pneumonia on the Respiratory and Intestinal Tract Microbiomes of Mice. Microbiol Spectr. 2023 Jun 15. doi: 10.1128/spectrum.03447-22
  • Apte S, Bhutda S, Ghosh S, Sharma K, Barton TE, Dibyachintan S, Sahay O, Roy S, Sinha AR, Adicherla H, Rakshit J, Tang S, Datey A, Santra S, Joseph J, Sasidharan S, Hammerschmidt S, Chakravortty D, Oggioni MR, Santra MK, Neill DR, Banerjee A.,2023 An innate pathogen sensing strategy involving ubiquitination of bacterial surface proteins. 
    Science Advances 2023 Mar 22. doi: 10.1126/sciadv.ade1851
  • Minhas V, Domenech A, Synefiaridou D, Straume D, Brendel M, Cebrero G, Liu X, Costa C Baldry M, Sirard JC, Perez C, Gisch N, Hammerschmidt S, Havarstein LS, Veening JW., 2023. Competence remodels the pneumococcal cell wall exposing key surface virulence factors that mediate increased host adherence. PLoS Biology 2023 Jan 30. doi: 10.1371/journal.pbio.3001990. Online ahead of print.

2022

  • Shajiei A, Liu L, Seinen J, Dieperink W, Hammerschmidt S, van Dijl JM, Harmsen HJM., 2022. Specific associations between fungi and bacteria in broncho-alveolar aspirates from mechanically ventilated intensive care unit patients. Virulence. 2022 Dec;13(1):2022-2031. doi: 10.1080/21505594.2022.2146568.
  • Barkowsky G, Abt C, Pöhner I, Bieda A, Hammerschmidt S, Jacob A, Kreikemeyer B, Patenge N., 2022. Antimicrobial Activity of Peptide-Coupled Antisense Peptide Nucleic Acids in Streptococcus pneumoniae. Microbiol. Spectr. 2022 Dec 21;10(6):e0049722. doi: 10.1128/spectrum.00497-22. Epub 2022 Nov 2.
  • Mills RO, Abdullah MR, Akwetey SA, Sappor DC, Bolivar JA, Gámez G, van der Linden MPG, Hammerschmidt S., 2022. Molecular Characterization and Antibiotic Susceptibility of Non-PCV13 Pneumococcal Serotypes among Vaccinated Children in Cape Coast, Ghana. Microorganisms. 2022 Oct 18;10(10):2054. doi: 103390/microorganisms10102054. 
  • Vidal JE, Bou Ghanem EN, Wu X, Wu K, Bai G, Hammerschmidt S., 2022. Editorial: Transmission, colonization, and molecular pathogenesis of pneumococcus. Front Cell Infect Microbiol. 2022 Sep 13;12:1028047.  doi: 10.3389/fcimb.2022.1028047. eCollection 2022.
  • Oehmcke-Hecht S, Maletzki C, Surabhi S, Siemens N, Khaimov V, John LM, Peter SM, Hammerschmidt S, Kreikemeyer B., 2022. Procoagulant Activity of Blood and Microvesicles Is Disturbed by Pneumococcal Pneumolysin, Which Interacts with Coagulation Factors.  J Innate Immun. 2022 Jul 15;1-17. doi: 10.1159/000525479. 
  • Wiebe F, Handtke S, Wesche J, Schnarre A, Palankar R, Wolff M, Jahn K, Voß F, Weißmüller S, Schüttrumpf J, Greinacher A, Hammerschmidt S., 2022. Polyvalent Immunoglobulin Preparations Inhibit Pneumolysin-Induced Platelet Destruction. Thromb Haemost. 2022 Jul;122(7):1147-1158.  doi: 10.1055/a-1723-1880. Epub 2021 Dec 16.
  • Schultz D, Cuypers F, Skorka SB, Rockstroh J, Gesell Salazar M, Krieger J, Albrecht D, Völker U, Hammerschmidt S, Lalk M, Siemens N, Methling K., 2022. Bioactive lipid screening during respiratory tract infections with bacterial and viral pathogens in mice. Metabolomics. 2022 Jun 10;18(6):39.  doi: 10.1007/s11306-022-01898-4.
  • Jahn K, Handtke S, Palankar R, Kohler TP, Wesche J, Wolff M, Bayer J, Wolz C, Greinacher A, Hammerschmidt S. 2022 α-hemolysin of Staphylococcus aureus impairs thrombus formation. J Thromb Haemost. 2022 Jun;20(6):1464-1475. doi: 10.1111/jth.15703. Epub 2022 Mar 27.
  • Schultz D, Cuypers F, Skorka SB, Rockstroh J, Gesell Salazar M, Krieger J, Albrecht D, Völker U, Hammerschmidt S, Lalk M, Siemens N, Methling K, 2022. Bioactive lipid screening during respiratory tract infections with bacterial and viral pathogens in mice. Metabolomics. 2022 Jun 10;18(6):39. doi: 10.1007/s11306-022-01898-4.
  • Jahn K, Shumba P, Quach P, Müsken M, Wesche J, Greinacher A, Rajagopal L, Hammerschmidt S, Siemens N. 2022. Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process. Cells. 2022 May 13;11(10):1637. doi: 10.3390/cells11101637.
  • Jahn K, Kohler TP, Swiatek L-S, Wiebe S, Hammerschmidt S 2022. Platelets, Bacterial Adhesins and the Pneumococcus. Cells 2022 Mar 25;11(7):1121. doi: 10.3390/cells11071121.
  • Kopenhagen A, Ramming I, Camp B, Hammerschmidt S, Fulde M, Müsken M, Steinert M, Bergmann S. 2022 Streptococcus pneumoniae Affects Endothelial Cell Migration in Microfluidic Circulation. Front Microbiol. 2022 Mar 25;13:852036. doi: 10.3389/fmicb.2022.852036. eCollection 2022.
  • Paulikat AD, Tölken LE, Jachmann LH, Burchhardt G, Hammerschmidt S, Siemens N. 2022. Streptococcus pneumoniae Impairs Maturation of Human Dendritic Cells and Consequent Activation of CD4+ T Cells via Pneumolysin. J Innate Immun. 2022 Mar 4;1-12.  doi: 10.1159/000522339 Online ahead of print.
  • Sura T, Gering V, Cammann C, Hammerschmidt S, Maaß S, Seifert U, Becher D. 2022. Streptococcus pneumoniae and Influenza A Virus Co-Infection Induces Altered Polyubiquitination in A549 Cells. Front Cell Infect Microbiol. 2022 Feb 24;12:817532. doi: 10.3389/fcimb.2022.817532. eCollection 2022.
  • Mills RO, Abdullah MR, Akwetey SA, Sappor DC, Gámez G, Hammerschmidt S. 2022. Molecular Epidemiology of Multidrug-Resistant Pneumococci among Ghanaian Children under Five Years Post PCV13 Using MLST. Microorganisms. 2022 Feb 19;10(2):469. doi: 10.3390/microorganisms10020469.
  • Kaplonek P, Yao L, Reppe K, Voß F, Kohler T, Ebner F, Schäfer A, Blohm U, Priegue P, Bräutigam M, Pereira CL, Parameswarappa SG, Emmadi M, Ménová P, Witzenrath M, Hammerschmidt S, Hartmann S, Sander LE, Seeberger PH. 2022. A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae. Vaccine 2022 Feb 11;40(7):1038-1046. doi: 10.1016/j.vaccine.2021.12.068. Epub 2022 Jan 13.

2021

  • Wiebe, F., S. Handtke, J. Wesche, A. Schnarre, R. Palankar, M. Wolff, K. Jahn, F. Voss, S. Weissmuller, J. Schuttrumpf, A. Greinacher,  Hammerschmidt S. 2021. Polyvalent immunoglobulin preparations inhibit pneumolysin-induced platelet destruction. Thrombosis and Haemostasis 2021 Dec 16. doi: 10.1055/a-1723-1880. Online ahead of print. PMID: 34918314
  • Ali MQ, Kohler TP, Schulig L, Burchhardt G, Hammerschmidt S. 2021. Pneumococcal Extracellular Serine Proteases: Molecular Analysis and Impact on Colonization and Disease. Front Cell Infect Microbiol. 2021 Nov 1;11:763152. doi: 10.3389/fcimb.2021.763152. eCollection 2021.
  • Cuypers F, Schäfer A, Skorka SB, Surabhi S, Tölken LA, Paulikat AD, Kohler TP, Otto SA, Mettenleiter TC, Hammerschmidt S, Blohm U, Siemens N. 2021. Innate immune responses at the asymptomatic stage of influenza A viral infections of Streptococcus pneumoniae colonized and non-colonized mice. Sci Rep. 2021 Oct 18;11(1):20609. doi: 10.1038/s41598-021-00211-y
  • Surabhi, S., L.H. Jachmann, M. Lalk, S. Hammerschmidt, K. Methling, and N. Siemens. 2021. Bronchial Epithelial Cells Accumulate Citrate Intracellularly in Response to Pneumococcal Hydrogen Peroxide. ACS Infect Dis 7(11):2971-2978. doi: 10.1021/acsinfecdis.1c00372. Epub 2021 Oct. 8
  • Sura, T., S. Surabhi, S. Maass, S. Hammerschmidt, N. Siemens, and D. Becher. 2021. The global proteome and ubiquitinome of bacterial and viral co-infected bronchial epithelial cells. J Proteomics. 2022 Jan 6;250:104387. doi: 10.1016/j.jprot.2021.104387. Epub 2021 Sep 30.
  • Surabhi, S., L.H. Jachmann, P. Shumba, G. Burchhardt, S. Hammerschmidt, and N. Siemens. 2021. Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1beta Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells. J Innate Immun. 2022;14(3):192-206. doi: 10.1159/000517855. Epub 2021 Aug 6.
  • Hirschmann, S., A. Gomez-Mejia, T.P. Kohler, F. Voss, M. Rohde, M. Brendel, and S. Hammerschmidt. 2021. The Two-Component System 09 of Streptococcus pneumoniae Is Important for Metabolic Fitness and Resistance during Dissemination in the Host. Microorganisms. 2021 Jun 23;9(7):1365. doi: 103390/microorganisms9071365.
  • Safari, D., F. Valentiya, K. Salsabila, W.T. Paramaiswari, W. Tafroji, S. Hammerschmidt, and S.R. Hadinegoro. 2021. The prevalence of pilus islets in Streptococcus pneumoniae isolates from healthy children in Indonesia. Access Microbiol. 2020 Dec 3;3(1):acmi000184. doi: 10.1099/acmi.0.0000184. eCollection 2021.

  • Hirschmann S, Gómez-Mejia A, Mäder U, Karsunke J, Driesch D, Rohde M, Häussler S, Burchhardt G, Hammerschmidt S(2021) The Two-Component System 09 Regulates Pneumococcal Carbohydrate Metabolism and Capsule Expression. Microorganisms. 2021 Feb 24;9(3):468. doi: 10.3390/microorganisms9030468. PMID: 33668344

  • Ali MQ, Kohler TP Burchhardt G, Wüst A, Henck N, Bolsmann R, Voß F and Hammerschmidt S (2021). Extracellular Pneumococcal Serine Proteases Affect Nasopharyngeal Colonization. Front. Cell. Infect. Microbiol. 2021 Feb 15;10:613467. doi: 10.3389/fcimb.2020.613467. eCollection 2020.

  • Abdullah, M.R., M.T. Batuecas, F. Jennert, F. Voss, P. Westhoff, T.P. Kohler, R. Molina, S. Hirschmann, M. Lalk, J.A. Hermoso, and S. Hammerschmidt  (2021) Crystal Structure and Pathophysiological Role of the Pneumococcal Nucleoside-binding Protein PnrA. J Mol Biol 433:166723.
  • Seinen J, Engelke R, Abdullah MR, Voß F, Michalik S, Dhople VM, Dieperink W, de Smet AMGA, Völker U, van Dijl JM, Schmidt F, Hammerschmidt S (2021) Sputum Proteome Signatures of Mechanically Ventilated Intensive Care Unit Patients Distinguish Samples with or without Anti-pneumococcal Activity. mSystems. 2021 Mar 2;6(2):e00702-20. doi: 10.1128/mSystems.00702-20. PMID: 33653939
  • Du S, Vilhena C, King S, Sahagún-Ruiz A, Hammerschmidt S, Skerka C, Zipfel PF (2021). Molecular analyses identifies new domains and structural differences among Streptococcus pneumoniae immune evasion proteins PspC and Hic. Sci Rep 11, 1701. doi: 10.1038/s41598-020-79362-3

2020

  • Jahn K, Handtke S, Palankar R, Weissmuller S, Nouailles G, Kohler TP, Wesche J, Rohde M, Heinz C, Aschenbrenner AF, Wolff M, Schuttrumpf J, Witzenrath M, Hammerschmidt S* and Greinacher A* (2020). Pneumolysin induces platelet destruction, not platelet activation, which can be prevented by immunoglobulin preparations in vitro. Blood Adv 4:6315-6326. *Correspondence
  • Abdullah MR, Batuecas MT, Jennert F, Voß F, Westhoff P, Kohler TP, Molina R, Hirschmann S, Lalk M, Hermoso JA, Hammerschmidt S (2020). Crystal Structure and Pathophysiological Role of the Pneumococcal Nucleoside-binding Protein PnrA, Journal of Molecular Biology Volume 433, Issue 2, 22 January 2021, 166723. https://doi.org/10.1016/j.jmb.2020.11.022
  • Mills RO, Abdullah MR, Akwetey SA, Sappor DC, Cole I, Baffuor-Asare M, Bolivar JA, Gamez G, van der Linden MPG, Hammerschmidt S (2020). Post-Vaccination Streptococcus pneumoniae Carriage and Virulence Gene Distribution among Children Less Than Five Years of Age, Cape Coast, Ghana. Microorganisms 8:
  • Mücke, P.A., A. Ostrzinski, S. Hammerschmidt, S. Maass, and D. Becher. 2020. Proteomic Adaptation of Streptococcus pneumoniae to the Antimicrobial Peptide Human Beta Defensin 3 (hBD3) in Comparison to Other Cell Surface Stresses. Microorganisms 8:
  • Büttner, H., M. Perbandt, T. Kohler, A. Kikhney, M. Wolters, M. Christner, M. Heise, J. Wilde, S. Weisselberg, A. Both, C. Betzel, S. Hammerschmidt, D. Svergun, M. Aepfelbacher, and H. Rohde. 2020. A Giant Extracellular Matrix Binding Protein of Staphylococcus epidermidis Binds Surface-Immobilized Fibronectin via a Novel Mechanism. mBio 11:
  • Voß F., L.F. van Beek, D. Schwudke, T.H.A. Ederveen, F.J. van Opzeeland, D.Thalheim, S. Werner, M.I. de Jonge and S. Hammerschmidt (2020) Lipidation of pneumococcal antigens leads to improved immunogenicity and protection. Vaccines (Basel) 8(2):E310. doi: 10.3390/vaccines8020310.
  • Devraj G,  Guerit S, Seele J, Macas J, Braczynski A, Ballhorn W, Günther S, Ogunshola L,  Mittelbronn M, Ködel U, Monoranu C, Plate K.H., Hammerschmidt S, Nau R, Devraj K,  Kempf V.A.J. (2020) HIF-1 α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis. Acta Neuropathol 140:183-208. doi: 10.1007/s00401-020-02174-2. PMID: 32529267.
  • Cuypers, F., B. Klabunde, M. Gesell Salazar, S. Surabhi, S.B. Skorka, G. Burchhardt, S. Michalik, T. Thiele, M. Rohde, U. Volker, S. Hammerschmidt, and N. Siemens. 2020. Adenosine Triphosphate Neutralizes Pneumolysin-induced Neutrophil Activation. J Infect Dis 222:1702-1712. doi: 10.1093/infdis/jiaa277. PMID: 32445565
  • Wolff, M., S. Handtke, R. Palankar, J. Wesche, T.P. Kohler, C. Kohler, Y. Gruel, S. Hammerschmidt, and A. Greinacher. 2020. Activated platelets kill Staphylococcus aureus, but not Streptococcus pneumoniae-The role of FcgammaRIIa and platelet factor 4/heparinantibodies. J Thromb Haemost 18:1459-1468.
  • Sadowy, E., A. Bojarska, A. Kuch, A. Skoczynska, K.A. Jolley, M.C.J. Maiden, A.J. van Tonder, S. Hammerschmidt, and W. Hryniewicz. 2020. Relationships among streptococci from the mitis group, misidentified as Streptococcus pneumoniae. Eur J Clin Microbiol Infect Dis 39:1865-1878. doi: 10.1007/s10096-020-03916-6. PMID: 32409955
  • Schultz, D., S. Surabhi, N. Stelling, M. Rothe, K.S. Group, K. Methling, S. Hammerschmidt, N. Siemens, and M. Lalk. 2020. 16HBE Cell Lipid Mediator Responses to Mono and Co-Infections with Respiratory Pathogens. Metabolites 10(3). pii: E113. doi: 10.3390/metabo10030113. 
  • Mücke, P.A., S. Maass, T.P. Kohler, S. Hammerschmidt, and D. Becher. 2020. Proteomic Adaptation of Streptococcus pneumoniaeto the Human Antimicrobial Peptide LL-37. Microorganisms 8(3). pii: E413. doi: 10.3390/microorganisms8030413.
  • Hirschfeld, C., A. Gomez-Mejia, J. Bartel, C. Hentschker, M. Rohde, S. Maass, S. Hammerschmidt, and D. Becher. 2020. Proteomic Investigation Uncovers Potential Targets and Target Sites of Pneumococcal Serine-Threonine Kinase StkP and Phosphatase PhpP. Frontiers in Microbiology 10:3101. doi: 10.3389/fmicb.2019.03101. eCollection 2019.
  • Hentschker, C., S. Maass, S. Junker, M. Hecker, S. Hammerschmidt, A. Otto, and D. Becher. 2020. Comprehensive Spectral Library from the Pathogenic Bacterium Streptococcus pneumoniae with Focus on Phosphoproteins. J Proteome Res 2020 Mar 23. doi: 10.1021/acs.jproteome.9b00615. [Epub ahead of print]

2019

  • Seinen J, Dieperink W, Mekonnen SA, Lisotto P, Harmsen HJM, Hiemstra B, Ott A, Schultz D, Lalk M, Oswald S, Hammerschmidt S*,de Smet AMGA, van Dijl JM*. (2019) Heterogeneous antimicrobial activity in broncho-alveolar aspirates from mechanically ventilated intensive care unit patients. Virulence 10:879-891. 

  • Schmidt, F., N. Kakar, T.C. Meyer, M. Depke, I. Masouris, G. Burchhardt, A. Gomez-Mejia, V. Dhople, L.S. Havarstein, Z. Sun, R.L. Moritz, U. Volker, U. Koedel, and S. Hammerschmidt. 2019. In vivo proteomics identifies the competence regulon and AliB oligopeptide transporter as pathogenic factors in pneumococcal meningitis. PLoS Pathog 15:e1007987.
  • Olotu, C., F. Lehmensiek, B. Koch, M. Kiefmann, A.K. Riegel, S. Hammerschmidt, and R. Kiefmann. 2019. Streptococcus pneumoniae inhibits purinergic signaling and promotes purinergic receptor P2Y2 internalization in alveolar epithelial cells. J Biol Chem 294(34): 12795-12806. doi: 10.1074/jbc.RA118.007236.
  • Hammerschmidt S, Rohde M, Preissner KT. 2019. Extracellular Matrix Interactions with Gram-Positive Pathogens. Microbiol Spectr. 7(2). doi: 10.1128/microbiolspec. GPP3-0041-2018. Review. PMID: 31004421

  • Jagau H, Behrens IK, Lahme K, Lorz G, Köster RW, Schneppenheim R, Obser T, Brehm MA, König G, Kohler TP, Rohde M, Frank R, Tegge W, Fulde M, Hammerschmidt S, Steinert M, Bergmann S. (2019) Von Willebrand Factor Mediates Pneumococcal Aggregation and Adhesion in Blood Flow.Front Microbiol. 26;10:511. doi: 10.3389/fmicb.2019.00511. eCollection 2019

  • Hammerschmidt, S., and M. Rohde. 2019. Electron Microscopy to Study the Fine Structure of the Pneumococcal Cell.Methods in molecular biology1968:13-33.
  • Nerlich, A., A.M. Lapschies, T.P. Kohler, I. Cornax, I. Eichhorn, O. Goldmann, P. Krienke, S. Bergmann, V. Nizet, S. Hammerschmidt, M. Rohde, and M. Fulde. 2019. Homophilic protein interactions facilitate bacterial aggregation and IgG-dependent complex formation by the Streptococcus canis M protein SCM. Virulence10:194-206.
  • Binsker, U., T.P. Kohler, and S. Hammerschmidt. 2019. Contribution of Human Thrombospondin-1 to the Pathogenesis of Gram-Positive Bacteria. J Innate Immun 1-13.
  • Krauel, K., P. Preusse, T.E. Warkentin, C. Trabhardt, S. Brandt, I. Jensch, M. Mandelkow, E. Hammer, S. Hammerschmidt, and A. Greinacher. 2019. Fibronectin modulates formation of PF4/heparin complexes and is a potential factor for reducing risk of developing HIT. Blood133:978-989.
  • Haleem, K.S., Y.M. Ali, H. Yesilkaya, T. Kohler, S. Hammerschmidt, P.W. Andrew, W.J. Schwaeble, and N.J. Lynch. 2019. The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface. Infection and Immunity 87(1). pii: e00742-18. doi: 10.1128/IAI.00742-18.

2018

  • Bulow, S., L. Zeller, M. Werner, M. Toelge, J. Holzinger, C. Entzian, T. Schubert, F. Waldow, N. Gisch, S. Hammerschmidt, and A. Gessner. 2018. Bactericidal/Permeability-Increasing Protein Is an Enhancer of Bacterial Lipoprotein Recognition. Frontiers in immunology9:2768.
  • Voß F, Kohler TP, Meyer T, Abdullah MR, van Opzeeland FJ, Saleh M, Michalik S, van Selm S, Schmidt F, De Jonge MI and Hammerschmidt S (2018) Intranasal vaccination with lipoproteins confers protection against pneumococcal colonisation. Frontiers in immunology 9:2405. doi: 10.3389/fimmu.2018.02405. eCollection 2018. PMID: 30405609 https://doi.org/10.3389/fimmu.2018.02405
  • Waldow, F., T.P. Kohler, N. Hess, D. Schwudke, S. Hammerschmidt, and N. Gisch. 2018. Attachment of phosphorylcholine residues to pneumococcal teichoic acids and modification of substitution patterns by the phosphorylcholine esterase. J Biol Chem293:10620-10629.
  • Udden F, Filipe M, Reimer A, Paul M, Matuschek E, Thegerstrom J, Hammerschmidt S, Pelkonen T, Riesbeck K. 2018. Aerobic bacteria associated with chronic suppurative otitis media in Angola. Infect Dis Poverty 7: 42
  • Palankar R, Kohler TP, Krauel K, Wesche J, Hammerschmidt S, Greinacher A. 2018. Platelets kill bacteria by bridging innate and adaptive immunity via platelet factor 4 and FcgammaRIIA. Journal of thrombosis and haemostasis : JTH16:1187-1197.
  • Palankar R, Binsker U, Haracska B, Wesche J, Greinacher A, Hammerschmidt S. 2018. Interaction between the Staphylococcus aureus extracellular adherence protein Eap and its subdomains with platelets. International journal of medical microbiology : IJMM308:683-691.
  • Meinel C, Sparta G, Dahse HM, Horhold F, Konig R, Westermann M, Coldewey SM, Cseresnyes Z, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF. 2018. Streptococcus pneumoniae From Patients With Hemolytic Uremic Syndrome Binds Human Plasminogen via the Surface Protein PspC and Uses Plasmin to Damage Human Endothelial Cells. J Infect Dis 217: 358-70.
  • Hoyer, J., J. Bartel, A. Gomez-Mejia, M. Rohde, C. Hirschfeld, N. Hess, T. Sura, S. Maass, S. Hammerschmidt, and D. Becher. 2018. Proteomic response of Streptococcus pneumoniae to iron limitation. International journal of medical microbiology : IJMM 308:713-721.
  • Leonard A, Gierok P, Methling K, Gomez-Mejia A, Hammerschmidt S, Lalk M. 2018. Metabolic inventory of Streptococcus pneumoniae growing in a chemical defined environment. International journal of medical microbiology : IJMM 308:705-712.
  • Gomez-Mejia, A., G. Gamez, S. Hirschmann, V. Kluger, H. Rath, S. Bohm, F. Voss, N. Kakar, L. Petruschka, U. Volker, R. Bruckner, U. Mader, and S. Hammerschmidt. 2018. Pneumococcal Metabolic Adaptation and Colonization Are Regulated by the Two-Component Regulatory System 08. mSphere3:
  • Gomez-Mejia, A., G. Gamez, and S. Hammerschmidt. 2018. Streptococcus pneumoniae two-component regulatory systems: The interplay of the pneumococcus with its environment. International journal of medical microbiology : International Journal of Medical Microbiology: 308:722-737
  • Gámez G, Castro A, Gómez-Mejia A, Gallego M, Bedoya A, Camargo M, and Hammerschmidt S. (2018) The variome of pneumococcal virulence factors and regulators. BMC Genomics. 19(1):10. doi: 10.1186/s12864-017-4376-0.
  • Fritscher J, Amberger D, Dyckhoff S, Bewersdorf JP, Masouris I, Voelk S, Hammerschmidt S, Schmetzer HM, Klein M, Pfister HW, Koedel U. 2018. Mast Cells Are Activated by Streptococcus pneumoniae In Vitro but Dispensable for the Host Defense Against Pneumococcal Central Nervous System Infection In Vivo. Front Immunol 9: 550 
  • Binsker U, Palankar R, Wesche J, Kohler TP, Prucha J, Burchhardt G, Rohde M, Schmidt F, Broker BM, Mamat U, Pane-Farre J, Graf A, Ebner P, Greinacher A, Hammerschmidt S. 2018. Secreted Immunomodulatory Proteins of Staphylococcus aureus Activate Platelets and Induce Platelet Aggregation. Thromb Haemost 118: 745-57    

2017

  • Heß N, Waldow F, Kohler TP, Rohde M, Kreikemeyer B, Gómez-Mejia A, Hain T, Schwudke D, Vollmer W, Hammerschmidt S*, Gisch N* (2017) Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae. Nat Commun. 2017 Dec 12;8(1):2093. doi: 10.1038/s41467-017-01720-z. PMID: 29233962. * corresponding authors
  • Siemens N, Oehmcke-Hecht S, Mettenleiter TC, Kreikemeyer B, Valentin-Weigand P, Hammerschmidt S. 2017. Port d'Entree for Respiratory Infections - Does the Influenza A Virus Pave the Way for Bacteria? Front Microbiol 8: 2602  
  • Kanwal, S., I. Jensch, G.J. Palm, M. Bronstrup, M. Rohde, T.P. Kohler, D. Somplatzki, W. Tegge, H.F. Jenkinson & S. Hammerschmidt (2017) Mapping the recognition domains of pneumococcal fibronectin-binding proteins PavA and PavB demonstrates a common pattern of molecular interactions with fibronectin type III repeats. Mol Microbiol 105: 839-859.
  • Kress, E., J. Merres, L.J. Albrecht, S. Hammerschmidt, T. Pufe, S.C. Tauber & L.O. Brandenburg, (2017) CRAMP deficiency leads to a pro-inflammatory phenotype and impaired phagocytosis after exposure to bacterial meningitis pathogens. Cell Commun Signal 15: 32.
  • Michalik, S., M. Depke, A. Murr, M. Gesell Salazar, U. Kusebauch, Z. Sun, T.C. Meyer, K. Surmann, H. Pfortner, P. Hildebrandt, S. Weiss, L.M. Palma Medina, M. Gutjahr, E. Hammer, D. Becher, T. Pribyl, S. Hammerschmidt, E.W. Deutsch, S.L. Bader, M. Hecker, R.L. Moritz, U. Mader, U. Volker & F. Schmidt, (2017) A global Staphylococcus aureus proteome resource applied to the in vivo characterization of host-pathogen interactions. Sci Rep 7: 9718.
  • Schauer, A.E., T.E. Klassert, C. von Lachner, D. Riebold, A. Schneeweiss, M. Stock, M.M. Muller, S. Hammerschmidt, P. Bufler, U. Seifert, K. Dietert, C.A. Dinarello, M.F. Nold, A.D. Gruber, C.A. Nold-Petry & H. Slevogt, (2017) IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia. J Innate Immun 9: 403-418.
  • Zierhut, M., S. Dyckhoff, I. Masouris, M. Klein, S. Hammerschmidt, H.W. Pfister, K. Ayata, M. Idzko & U. Koedel, (2017) Role of purinergic signaling in experimental pneumococcal meningitis. Sci Rep 7: 44625.
  • Mühlenkamp, M.C., Hallstrom, T., Autenrieth, I.B., Bohn, E., Linke, D., Rinker, J., Riesbeck, K., Singh, B., Leo, J.C., Hammerschmidt, S., Zipfel, P.F. and Schütz, M.S. (2017). Vitronectin Binds to a Specific Stretch within the Head Region of Yersinia adhesin A and thereby modulates Yersinia enterocolitica host interaction. J Innate Immun. 9, 33-51.
  • Binsker, U., Kohler, T.P., Krauel, K., Kohler, S., Habermeyer, J., Schwertz, H., Hammerschmidt, S. (2017). Serotype 3 pneumococci sequester platelet-derived human thrombospondin-1 via the adhesin and immune evasion protein Hic. J Biol Chem. 292, 5770-83.
  • Bergmann, S., Eichhorn, I., Kohler, T.P., Hammerschmidt, S., Goldmann, O., Rohde, M., Fulde, M. (2017). SCM, the M Protein of Streptococcus canis binds immunoglobulin G. Front Cell Infect Microbiol. 7, 80.

2016

  • Javier Gutiérrez-Fernández, Malek Saleh, Martín Alcorlo, Alejandro Gómez M., David Pantoja-Uceda, Miguel A. Treviño, Franziska Voß, Mohammed R. Abdullah, Sergio Galán-Bartual, Jolien Seinen, Pedro A. Sánchez-Murcia, Federico Gago, Marta Bruix, Sven Hammerschmidt* and Juan A. Hermoso* (2016) Modular architecture and unique teichoic acid recognition features of choline-binding protein L (CbpL) Contributing to Pneumococcal Pathogenesis. Scientific Reports 6:38094.*corresponding authors
  • Zakrzewicz D, Bergmann S, Didiasova M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Lochnit G, Schaefer L, Hammerschmidt S, Preissner KT, Wygrecka M. (2016) Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells. Scientific Reports 6:37758. 
  • Hammerschmidt S. (2016) Special Issue on 'Microbe-host interactions'. FEBS Lett. 590(21):3703-3704.
  • Kohler S, Voß F, Gómez Mejia A, Brown JS, Hammerschmidt S (2016) Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasion. FEBS Lett. 590(21):3820-3839. (Review)
  • Ahnert P, Creutz P, Scholz M, Schütte H, Engel C, Hossain H, Chakraborty T, Bauer M, Kiehntopf M, Völker U, Hammerschmidt S, Loeffler M, Suttorp N; PROGRESS study group (2016) PROGRESS - prospective observational study on hospitalized community acquired pneumonia. BMC Pulm Med. 2016 Jul 28;16(1):108.
  • Ribes S*, Abdullah M, Saleh M, Hanisch U, Nau R, Hammerschmidt S. Thioredoxins and Methionine Sulfoxide Reductases in the Pathophysiology of Pneumococcal Meningitis. JOURNAL OF INFECTIOUS DISEASES. 2016; 214(6):953-961.
  • Banaschik R*, Burchhardt G, Zocher K, Hammerschmidt S, Kolb J, Weltmann K. Comparison of pulsed corona plasma and pulsed electric fields for the decontamination of water containing Legionella pneumophila as model organism. BIOELECTROCHEMISTRY. 2016; 112:83-90.  
  • Kohler TP*, Scholz A, Kiachludis D, Hammerschmidt S. Induction of Central Host Signaling Kinases during Pneumococcal Infection of Human THP-1 Cells. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2016; 6.
  • Hallström T*, Singh B, Kraiczy P, Hammerschmidt S, Skerka C, Zipfel P, Riesbeck K. Conserved Patterns of Microbial Immune Escape: Pathogenic Microbes of Diverse Origin Target the Human Terminal Complement Inhibitor Vitronectin via a Single Common Motif. (Originalartikel) PLOS ONE. 2016; 11(1):e0147709. 
  • Nübel C*, Appel B, Hospach I, Mai M, Krasteva N, Nelles G, Petruschka L, Müller S. Challenges and Opportunities in the Development of Aptamers for TNFα. (Originalartikel) APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY. 2016.  
  • Kulkarni U*, Karsten C, Kohler T, Hammerschmidt S, Bommert K, Tiburzy B, Meng L, Thieme L, Recke A, Ludwig R, Pollok K, Kalies K, Bogen B, Boettcher M, Kamradt T, Hauser A, Langer C, Huber-Lang M, Finkelman F, Köhl J, Wong D, Manz R. IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration. THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2016; 137(5):1487-1497.

2015

  • Binsker U*, Kohler T, Krauel K, Kohler S, Schwertz H, Hammerschmidt S. Pneumococcal Adhesins PavB and PspC Are Important for the Interplay with Human Thrombospondin-1. (Originalartikel) JOURNAL OF BIOLOGICAL CHEMISTRY. 2015; 290(23):14542-14555.
  • Brandt S*, Krauel K, Jaax M, Renné T, Helm C, Hammerschmidt S, Delcea M, Greinacher A. Polyphosphates form antigenic complexes with platelet factor 4 (PF4) and enhance PF4-binding to bacteria. (Originalartikel) THROMBOSIS AND HAEMOSTASIS. 2015; 114(6):1189-1198.
  • Kohler S*, Hallström T, Singh B, Riesbeck K, Spartà G, Zipfel P, Hammerschmidt S. Binding of vitronectin and Factor H to Hic contributes to immune evasion of Streptococcus pneumoniae serotype 3. (Originalartikel) THROMBOSIS AND HAEMOSTASIS. 2015; 113(1):125-142.
  • Loose M*, Hudel M, Zimmer K, Garcia E, Hammerschmidt S, Lucas R, Chakraborty T, Pillich H. Pneumococcal hydrogen peroxide-induced stress signaling regulates inflammatory genes. (Originalartikel) JOURNAL OF INFECTIOUS DISEASES. 2015; 211(2):306-316.
  • Reppe K*, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber A, Suttorp N, Witzenrath M. Pulmonary Immunostimulation with MALP-2 in Influenza Virus-Infected Mice Increases Survival after Pneumococcal Superinfection. (Originalartikel) INFECTION AND IMMUNITY. 2015; 83(12):4617-4629.
  • Zahlten J*, Kim Y, Doehn J, Pribyl T, Hocke A, García P, Hammerschmidt S, Suttorp N, Hippenstiel S, Hübner R. Streptococcus pneumoniae-Induced Oxidative Stress in Lung Epithelial Cells Depends on Pneumococcal Autolysis and Is Reversible by Resveratrol. (Originalartikel) JOURNAL OF INFECTIOUS DISEASES. 2015; 211(11):1822-1830.

2014

  • Schulz C, Gierok P, Petruschka L, Lalk M, Mäder U, Hammerschmidt S. (2014) Regulation of the Arginine Deiminase System by ArgR2 Interferes with Arginine Metabolism and Fitness of Streptococcus pneumoniae. MBio. 2014 Dec 23;5(6). pii: e01858-14. doi: 10.1128/mBio.01858-14.
  • M.R. Abdullah, J. Gutiérrez-Fernández, T. Pribyl, N. Gisch, M. Saleh, M. Rohde, L. Petruschka, G. Burchhardt, D. Schwudke, J.A. Hermoso and S. Hammerschmidt (2014) Structure of the pneumococcal L,D-carboxypeptidase DacB and pathophysiological effects of disabled cell wall hydrolases DacA and DacB.  Mol Microbiol. 93(6):1183-1206
  • Tauseef M. Asmat, Vaibhav Agarwal, Malek Saleh, and Sven Hammerschmidt (2014) Endocytosis of Streptococcus pneumoniae via the polymeric immunoglobulin receptor of epithelial cells relies on clathrin and caveolin dependent mechanisms. J Med Microbiol. 304(8):1233-46
  • Mohan S, Hertweck C, Dudda A, Hammerschmidt, S, Skerka C, Hallström T, Zipfel PF. (2014) Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein.  Mol Immunol. 62(1):249-264.
  • M. Klein, M.C. Brouwer, B. Angele, M. Geldhoff, G. Marquez, R. Varona, G. Häcker, H. Schmetzer, H. Häcker, S. Hammerschmidt, A. van der Ende, H.W. Pfister, D. van de Beek, and U. Koedel (2014) Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis. PLoSOne. 2014 Apr 3;9(4):e93057. doi: 10.1371/journal.pone.0093057.
  • T. Pribyl, M. Moche, A. Dreisbach, J.J. Bijlsma, M. Saleh, M.R. Abdullah, M. Hecker, J.M. van Dijl, D. Becher, and S. Hammerschmidt (2014) Influence of impaired lipoprotein biogenesis on surface and exoproteome of Streptococcus pneumoniae. J Proteome Res 13(2):650-67. doi: 10.1021/pr400768v
  • Saleh M, M.R. Abdullah, C. Schulz, T. Kohler, T. Pribyl, I. Jensch, and S. Hammerschmidt (2014) Following in real time the impact of pneumococcal virulence factors in an acute mouse pneumonia model using bioluminescent bacteria. J Vis Exp: e51174. doi: 10.3791/51174.
  • www.jove.com/video/51174/following-real-time-impact-pneumococcal-virulence-factors-an-acute
  • Kohler TP, N. Gisch, U. Binsker, M. Schlag, K. Darm, U. Völker, U. Zähringer, S. Hammerschmidt (2014) Repeating structures of the major staphylococcal autolysin are essential for the interaction with human thrombospondin 1 and vitronectin.  J Biol Chem. 14;289(7):4070-4082. doi: 10.1074/jbc.M113.521229.

2013

  • Saleh, M., S.G. Bartual, M.R. Abdullah, I. Jensch, T.M. Asmat, L. Petruschka, T. Pribyl, M. Gellert, C.H. Lillig, H. Antelmann, J.A. Hermoso and S.Hammerschmidt (2013) Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence. EMBO Mol Med. 5: 1852-1870. doi:10.1002/emmm.201202435.
  • Schulz, C., and S. Hammerschmidt (2013) Exploitation of physiology and metabolomics to identify pneumococcal vaccine candidates. Expert Rev Vaccine 12(9): 1033-1045.
  • Bergmann, S., H. Schoenen, and S. Hammerschmidt (2013) The interaction between bacterial enolase and plasminogen promotes adherence of Streptococcus pneumoniae to epithelial and endothelial cells. Int J Med Microbiol 303 (8): 452-462.
  • Rosendahl, A., S. Bergmann, S. Hammerschmidt, O. Goldmann, and E. Medina (2013) Lung dendritic cells facilitate extrapulmonary bacterial dissemination during pneumococcal pneumonia. Front Cell Infect Microbiol 3:21. PMID: 23802100
  • Voss, S., T. Hallstroem, M. Saleh, G. Burchhardt, T. Pribyl, B. Singh, K. Riesbeck, P.F. Zipfel, and S. Hammerschmidt (2013) The choline-binding protein PspC of Streptococcus pneumoniae interacts with the C-terminal heparin-binding domain of vitronectin. J Biol Chem 288: 15614-15627. PMID: 23603906
  • Gisch, N.*, T. Kohler*, A.J. Ulmer, J. Muthing, T. Pribyl, K. Fischer, B. Lindner, S. Hammerschmidt, and U. Zahringer (2013) Structural reevaluation of Streptococcus pneumoniae lipoteichoic acid and new insights into its immunostimulatory potency. J Biol Chem.  288: 15654-15667. PMID: 23603911. * equal contribution
  • Hohne, C., M. Wenzel, B. Angele, S. Hammerschmidt, H. Hacker, M. Klein, A. Bierhaus, M. Sperandio, H.W. Pfister, and U. Koedel (2013) High mobility group box 1 prolongs inflammation and worsens disease in pneumococcal meningitis. Brain 136:1746-1759. PMID: 23518713
  • Zahlten, J., R. Steinicke, W. Bertrams, A.C. Hocke, S. Scharf, B. Schmeck, M. Witzenrath, S. Hammerschmidt, N. Suttorp, and S. Hippenstiel (2013) TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia. Eur Respir J 41:384-391. PMID: 22653776

2012

  • Krauel, K., C. Weber, S. Brandt, U. Zahringer, U. Mamat, A. Greinacher, and S. Hammerschmidt (2012) Platelet factor 4 binding to lipid A of Gram-negative bacteria exposes PF4/heparin-like epitopes. Blood.  120:3345-3352. PMID: 22942185
  • Agarwal, V., S. Hammerschmidt , S. Malm, S. Bergmann, K. Riesbeck, and A.M. Blom (2012) Enolase of Streptococcus pneumoniae Binds Human Complement Inhibitor C4b-Binding Protein and Contributes to Complement Evasion. J Immunol 189(7):3575-3584. PMID: 22925928
  • Voss, S., G. Gamez, and S. Hammerschmidt (2012) Impact of pneumococcal microbial surface components recognizing adhesive matrix molecules on colonization. Mol Oral Microbiol 27:246-256. PMID: 22759310
  • Asmat TM, Klingbeil K, Jensch I, Burchhardt G, Hammerschmidt S. (2012) Heterologous expression of pneumococcal virulence factor PspC on the surface of Lactococcus lactis confers adhesive properties. Microbiology 158:771-80. PMID: 22222496
  • Centanni M, Bergmann S, Turroni S, Hammerschmidt S, Chhatwal GS, Brigidi P, Candela M. (2012) TNF-alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes. Appl Environ Microbiol 78(7):2465-9. PMID:22287006
  • Gámez, G., and S. Hammerschmidt (2012) Combat pneumococcal infections: adhesins as candidates for protein-based vaccine development. Curr Drug Targets Curr Drug Target 13(3):323-337. PMID: 22206255
  • Haertel, T., E. Eylert, C. Schulz, L. Petruschka, P. Gierok, S. Grubmueller, M. Lalk, W. Eisenreich, and S. Hammerschmidt (2012) Characterization of the central carbon metabolism of Streptococcus pneumoniae by isotopologue profiling. J Biol Chem Biol Chem. 287(6):4260-4274. PMID: 22167202
  • Koppe, U., K. Hogner, J.M. Doehn, H.C. Muller, M. Witzenrath, B. Gutbier, S. Bauer, T. Pribyl, S. Hammerschmidt, J. Lohmeyer, N. Suttorp, S. Herold, and B. Opitz (2012) Streptococcus pneumoniae Stimulates a STING- and IFN Regulatory Factor 3-Dependent Type I IFN Production in Macrophages, which Regulates RANTES Production in Macrophages, Cocultured Alveolar Epithelial Cells, and Mouse Lungs. J Immunol 188(2):811-817. PMID: 22156592
  • Luttge, M., M. Fulde, S.R. Talay, A. Nerlich, M. Rohde, K.T. Preissner, S. Hammerschmidt, M. Steinert, T.J. Mitchell, G.S. Chhatwal, and S. Bergmann (2012) Streptococcus pneumoniae induces exocytosis of Weibel-Palade bodies in pulmonary endothelial cells. Cell Microbiol. 14(2):210-25. PMID: 21999205

2011

  • Hoegen, T., N. Tremel, M. Klein, B. Angele, H. Wagner, C. Kirschning, H.W. Pfister, A. Fontana, S. Hammerschmidt, and U. Koedel (2011) The NLRP3 Inflammasome Contributes to Brain Injury in Pneumococcal Meningitis and Is Activated through ATP-Dependent Lysosomal Cathepsin B Release. J Immunol 187: 5440-5451.
  • Greinacher A, Holtfreter B, Krauel K, Gätke D, Weber C, Ittermann T, Hammerschmidt S, Kocher T. (2011) Association of natural anti-platelet factor 4/heparin antibodies with periodontal disease. Blood 118:1395-1401.
  • Asmat T.M., V. Agarwal, S. Rath, J.P. Hildebrandt, and S.Hammerschmidt S (2011) Streptococcus pneumoniae infection of host epithelial cells via polymeric immunoglobulin receptor transiently induces calcium release from intracellular stores. J Biol Chem. 286(20):17861-17869.
  • Oschatz, C., C. Maas, B. Lecher, T. Jansen, J. Bjorkqvist, T. Tradler, R. Sedlmeier, P. Burfeind, S. Cichon, S. Hammerschmidt, W. Muller-Esterl, W.A. Wuillemin, G. Nilsson, and T. Renne (2011) Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo. Immunity 34:258-268.
  • Hartel, T., M. Klein, U. Koedel, M. Rohde, L. Petruschka and S. Hammerschmidt (2011) Impact of glutamine transporters on pneumococcal fitness under infection related conditions. Infect Immun. 79(1):44-58.
  • Kreikemeyer, B., G. Gamez, I. Margarit, J.C. Giard, S. Hammerschmidt, A. Hartke, and A. Podbielski (2011) Genomic organization, structure, regulation and pathogenic role of pilus constituents in major pathogenic Streptococci and Enterococci. Int J Med Microbiol 301(3):240-51.
  • Candela, M., S. Turroni, M. Centanni, J. Fiori, S. Bergmann, S. Hammerschmidt, and P. Brigidi (2011) Relevance of Bifidobacterium animalis subsp. lactis Plasminogen Binding Activity in the Human Gastrointestinal Microenvironment. Appl Environ Microbiol 77:7072-7076.
  • Krauel, K., C. Potschke, C. Weber, W. Kessler, B. Furll, T. Ittermann, S. Maier, S. Hammerschmidt, B. M. Broker and A. Greinacher (2011) Platelet factor 4 binds to bacteria inducing antibodies cross-reacting with the major antigen in heparin-induced thrombocytopenia. Blood 117:1370-1378.

2010

  • Agarwal, V., T. M. Asmat, N. I. Dierdorf, C. R. Hauck and S. Hammerschmidt (2010) Polymeric immunoglobulin receptor-mediated invasion of Streptococcus pneumoniae into host cells requires a coordinate signaling of SRC family of protein-tyrosine kinases, ERK, and c-Jun N-terminal kinase. J Biol Chem 285: 35615-35623.
  • Zahlten, J., R. Steinicke, B. Opitz, J. Eitel, D. N'Guessan P, M. Vinzing, M. Witzenrath, B. Schmeck, S. Hammerschmidt, N. Suttorp and S. Hippenstiel, (2010) TLR2- and nucleotide-binding oligomerization domain 2-dependent Kruppel-like factor 2 expression downregulates NF-kappa B-related gene expression. J Immunol 185: 597-604.
  • Agarwal, V.A., T.M. Asmat, S. Luo, I. Jensch, P.F. Zipfel, and S. Hammerschmidt (2010) Complement regulator factor H mediates a two-step uptake of Streptococcus pneumoniae by human cells. J Biol Chem 285: 23486-23495.
  • Jensch, I., G. Gamez, M. Rothe, S. Ebert, M. Fulde, D. Somplatzki, S. Bergmann, L. Petruschka, M. Rohde, R. Nau, and S. Hammerschmidt. (2010) PavB is a surface-exposed adhesin of Streptococcus pneumoniae contributing to nasopharyngeal colonization and airways infections. Mol Microbiol 77:22-43.
  • Kadioglu, A., H. Brewin, T. Härtel, J.L. Brittan, M. Klein, S. Hammerschmidt, and H.F. Jenkinson (2010) Pneumococcal protein PavA is involved in nasopharyngeal carriage and development of sepsis. Mol Oral Microbiol 25(1):50-60.
  • Candela M, Centanni M, Fiori J, Biagi E, Turroni S, Orrico C, Bergmann S, Hammerschmidt S, and Brigidi P. (2010) DnaK from Bifidobacterium animalis subsp. lactis is a surface exposed human plasminogen receptor up-regulated in response to bile salts. Microbiology. 2010 Jun;156:1609-18.
  • Ribes S, S. Ebert, T. Regen, A. Agarwal, S.C. Tauber, D. Czesnik, A. Spreer, S. Bunkowski, H. Eiffert, U.K. Hanisch, S. Hammerschmidt, and R. Nau (2010) Toll-like receptor stimulation enhances phagocytosis intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia. Infect Immun. 78(2):865-871.
  • Ribes S, S. Ebert, T. Regen, D. Czesnik, J. Scheffel, A. Zeug, S. Bunkowski, H. Eiffert, U.K. Hanisch, S. Hammerschmidt, and R. Nau (2010) Fibronectin stimulates Escherichia coli phagocytosis by microglial cells.Glia. 58:367–376.

2009

  • Noske, N., U. Kämmerer, M. Rohde, and S. Hammerschmidt (2009) Pneumococcal interaction with human dendritic cells: phagocytosis, survival and induced adaptive immune response is manipulated by PavA. J. Immunology 183: 1952-1963.
  • Weber C, Krueger A, Münk A, Bode C, Van Veldhoven PP, Gräler MH.(2009) Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice. J Immunol. 2009 Oct 1;183(7):4292-301. Epub 2009 Sep 11.
  • Candela, M., E.Biagi, M. Centanni, S. Turroni, M. Vici, F. Musiani, B. Vitali, S. Bergmann, S. Hammerschmidt, and P. Brigidi. (2009) Bifidobacterial enolase, a cell surface receptor for human plasminogen involved in the interaction with the host. Microbiology. 2009 Oct;155(Pt 10):3294-303. 
  • Niemann, S., B.E. Kehrel, C. Heilmann, C. Rennemeier, G. Peters and S. Hammerschmidt (2009) Pneumococcal association to platelets is mediated by soluble fibrin and supported by thrombospondin-1. Thrombosis and Haemostasis 2009 Oct;102(4):735-42.
  • Agarwal, V.A. and S. Hammerschmidt (2009) Cdc42 and PI3-kinase-Akt pathway are essential for PspC mediated internalization of pneumococci by respiratory epithelial cells. J Biol Chem 284(29): 19427-19436.
  • Cork AJ, Jergic S, Hammerschmidt S, Kobe B, Pancholi V, Benesch JL, Robinson CV, Dixon NE, Aquilina JA, Walker MJ (2009) Defining the structural basis of human basis of human plasminogen binding by streptococcal surface enolase. J Biol Chem. 284(25): 17129-17137.
  • Cron, L.E., H.J. Bootsma, N. Noske, P. Burghout, S. Hammerschmidt, and P.W.M. Hermans (2009) Surface-associated lipoprotein PpmA of Streptococcus pneumoniae is involved in colonization. Microbiology 155:2401-2410.
  • Ludlam A, Brunzelle J, Pribyl T, Xu X, Gatti D L, Ackerman S H. (2009) Chaperones of F1-ATPase. J Biol Chem 284(25):17138-17146.
  • Bergmann, S., Lang, A., Rohde, M., Agarwal, V., Rennemeier, C., Grashoff, C., Preissner, K.T., and Hammerschmidt, S. (2009) Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells. J Cell Science 122: 256-267
  • Ribes S, Ebert S, Czesnik D, Regen T, Zeug A, Bukowski S, Mildner A, Eiffert H, Hanisch UK, Hammerschmidt S, Nau R (2009) Toll-like receptor pre-stimulation increases phagocytosis of Escherichia coli DH5α and Escherichia coli K1 strains by murine microglial cells. Infect Immun. 77(1): 557-564.
  • Hammerschmidt, S. (2009) Surface-exposed adherence molecules of Streptococcus pneumoniae. Methods Mol Biol 470: 29-45.

2008

  • Zipfel, P.F., T. Hallström, S. Hammerschmidt,, and C. Skerka (2008) The complement fitness Factor H: Role in human diseases and for immune escape of pathogens. Vaccine 26S8: 167-174
  • Candela,M., G.Miccoli, S.Bergmann, S. Turroni, B. Vitali, S.Hammerschmidt and P.Brigidi (2008) Plasminogen-dependent proteolytic activity in Bifidobacterium lactis. Microbiology 154 (8): 2457 - 2462
  • Kolberg,J., S.Hammerschmidt, R.Frank, J.Jonak, H.Sanderova, and A.Aase (2008) The surface-associated elongation factor Tu is concealed for antibody binding on viable pneumococci and meningococci. FEMS Immunol. Med. Microbiol 53(2): 222-230.
  • Downie B R, Sanchez J, Knotgen H, Contreras-Jurado C, Gymnopoulos M, Weber C, Stuhmer W, Pardo L A (2008) Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors. J BIOL CHEM 283(52):36234-40

2007

  • Hocke,A.C., M.P.Lampe, M.Witzenrath, H.Mollenkopf, J.Zerrahn, B.Schmeck, U.Kessler, M.Krull, S.Hammerschmidt, S.Hippenstiel, H.Schutte, N.Suttorp, and S.Rosseau. 2007. Cell-specific interleukin-15 and interleukin-15 receptor subunit expression and regulation in pneumococcal pneumonia--comparison to chlamydial lung infection. Cytokine 38:61-73.
  • Candela,M., S.Bergmann, M.Vici, B.Vitali, S.Turroni, B.J.Eikmanns, S.Hammerschmidt, and P.Brigidi. 2007. Binding of human plasminogen to Bifidobacterium. J. Bacteriol. 189:5929-5936.
  • Rennemeier,C1, S.Hammerschmidt 1*, S.Niemann, S.Inamura, U.Zahringer, and B.E.Kehrel. 2007. Thrombospondin-1 promotes cellular adherence of gram-positive pathogens via recognition of peptidoglycan. FASEB J. 21:3118-3132. 1equal contribution; *correspondance
  • Hammerschmidt,S., V.Agarwal, A.Kunert, S.Haelbich, C.Skerka, and P.F.Zipfel. 2007. The host immune regulator factor H interacts via two contact sites with the PspC protein of Streptococcus pneumoniae and mediates adhesion to host epithelial cells. J. Immunol. 178:5848-5858.
  • Knaust,A., M.V.Weber, S.Hammerschmidt, S.Bergmann, M.Frosch, and O.Kurzai. 2007. Cytosolic proteins contribute to surface plasminogen recruitment of Neisseria meningitidis. J. Bacteriol. 189:3246-3255.

2006

  • Zhang,Q., J.Bernatoniene, L.Bagrade, J.C.Paton, T.J.Mitchell, S.Hammerschmidt, D.A.Nunez, and A.Finn (2006) Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children. Infect. Immun. 74:4735-4743.
  • Kolberg,J., A.Aase, S.Bergmann, T.K.Herstad, G.Rodal, R.Frank, M.Rohde, and S.Hammerschmidt (2006) Streptococcus pneumoniae enolase is important for plasminogen binding despite low abundance of enolase protein on the bacterial cell surface. Microbiology 152:1307-1317.
  • Braathen,R., A.Sandvik, G.Berntzen, S.Hammerschmidt, B.Fleckenstein, I.Sandlie, P.Brandtzaeg, F.E.Johansen, and V.Lauvrak (2006) Identification of a polymeric Ig receptor binding phage-displayed peptide that exploits epithelial transcytosis without dimeric IgA competition. J. Biol. Chem. 281:7075-7081.
  • Schmeck,B., S. Huber, K. Moog, J. Zahlten, A.C.Hocke, B.Opitz, S.Hammerschmidt, T.J. Mitchell, M. Kracht, S.Rosseau, N.Suttorp, and S.Hippenstiel (2006) Pneumococci induced TLR- and Rac-1 dependent NF-(kappa)B recruitment to the IL-8 promotor in lung epithelial cells. Tam. J. Physiol. Lung Cell Mol. Physiol 290: L730-737.
  • Hermans,P.W., P.V.Adrian, C.Albert, S.Estevao, T.Hoogenboezem, I.H.Luijendijk, T.Kamphausen, and S.Hammerschmidt (2006) The streptococcal lipoprotein rotamase A (SlrA) is a functional peptidyl-prolyl isomerase involved in pneumococcal colonization. J. Biol. Chem. 281:968-976.
  • Kurbatov L, Albrecht D,Herrmann H, Petruschka L (2006) Analysis of the proteome of Pseudomonas putida KT2440 grown on different sources of carbon and energy. ENVIRON MICROBIOL 8(3):466-78
  • Weber C, Mello D Q F, Downie B R, Suckow A, Stuhmer W, Pardo L A. (2006) Silencing the activity and proliferative properties of the human EagI Potassium Channel by RNA Interference. J BIOL CHEM 103(2):13030-13037.

2005

  • Bergmann,S., M.Rohde, K.T.Preissner, and S.Hammerschmidt. 2005. The nine residue plasminogen-binding motif of the pneumococcal enolase is the major cofactor of plasmin-mediated degradation of extracellular matrix, dissolution of fibrin and transmigration. Thromb. Haemost. 94:304-311.
  • N'Guessan,P.D., B.Schmeck, A.Ayim, A.C.Hocke, B.Brell, S.Hammerschmidt, S.Rosseau, N.Suttorp, and S.Hippenstiel. 2005. Streptococcus pneumoniae R6x induced p38 MAPK and JNK-mediated caspase-dependent apoptosis in human endothelial cells. Thromb. Haemost. 94:295-303.
  • Hammerschmidt,S., S.Wolff, A.Hocke, S.Rosseau, E.Muller, and M.Rohde. 2005. Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cells. Infect. Immun. 73:4653-4667.
  • Erttmann,K.D., A.Kleensang, E.Schneider, S.Hammerschmidt, D.W.Buttner, and M.Gallin. 2005. Cloning, characterization and DNA immunization of an Onchocerca volvulus glyceraldehyde-3-phosphate dehydrogenase (Ov-GAPDH). Biochim. Biophys. Acta 1741:85-94.
  • Pracht,D., C.Elm, J.Gerber, S.Bergmann, M.Rohde, M.Seiler, K.S.Kim, H.F.Jenkinson, R.Nau, and S.Hammerschmidt. 2005. PavA of Streptococcus pneumoniae modulates adherence, invasion, and meningeal inflammation. Infect. Immun. 73:2680-2689.

2004

  • Schmeck,B., J.Zahlten, K.Moog, L.van, V, S.Huber, A.C.Hocke, B.Opitz, E.Hoffmann, M.Kracht, J.Zerrahn, S.Hammerschmidt, S.Rosseau, N.Suttorp, and S.Hippenstiel. 2004. Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor. J. Biol. Chem. 279:53241-53247.
  • Ehinger,S., W.D.Schubert, S.Bergmann, S.Hammerschmidt, and D.W.Heinz. 2004. Plasmin(ogen)-binding alpha-enolase from Streptococcus pneumoniae: crystal structure and evaluation of plasmin(ogen)-binding sites. J. Mol. Biol. 343:997-1005.
  • Schaumburg,J., O.Diekmann, P.Hagendorff, S.Bergmann, M.Rohde, S.Hammerschmidt, L.Jansch, J.Wehland, and U.Karst. 2004. The cell wall subproteome of Listeria monocytogenes. Proteomics. 4:2991-3006.
  • Schmeck,B., R.Gross, P.D.N'Guessan, A.C.Hocke, S.Hammerschmidt, T.J.Mitchell, S.Rosseau, N.Suttorp, and S.Hippenstiel. 2004. Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium. Infect. Immun. 72:4940-4947.
  • Elm,C., M.Rohde, J.P.Vaerman, G.S.Chhatwal, and S.Hammerschmidt. 2004. Characterization of the interaction of the pneumococcal surface protein SpsA with the human polymeric immunoglobulin receptor (hpIgR). Indian J. Med. Res. 119 Suppl:61-65.
  • Bergmann,S., M.Rohde, G.S.Chhatwal, and S.Hammerschmidt. 2004. Characterization of plasmin(ogen) binding to Streptococcus pneumoniae. Indian J. Med. Res. 119 Suppl:29-32.
  • Opitz,B., A.Puschel, B.Schmeck, A.C.Hocke, S.Rosseau, S.Hammerschmidt, R.R.Schumann, N.Suttorp, and S.Hippenstiel. 2004. Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. J. Biol. Chem. 279:36426-36432.
  • Dave,S., S.Carmicle, S.Hammerschmidt, M.K.Pangburn, and L.S.McDaniel. 2004. Dual roles of PspC, a surface protein of Streptococcus pneumoniae, in binding human secretory IgA and factor H. J. Immunol. 173:471-477.
  • Godehardt,A.W., S.Hammerschmidt, R.Frank, and G.S.Chhatwal. 2004. Binding of alpha2-macroglobulin to GRAB (Protein G-related alpha2-macroglobulin-binding protein), an important virulence factor of group A streptococci, is mediated by two charged motifs in the DeltaA region. Biochem. J. 381:877-885.
  • Bergmann,S., M.Rohde, and S.Hammerschmidt. 2004. Glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pneumoniae is a surface-displayed plasminogen-binding protein. Infect. Immun. 72:2416-2419.
  • Elm,C., R.Braathen, S.Bergmann, R.Frank, J.P.Vaerman, C.S.Kaetzel, G.S.Chhatwal, F.E.Johansen, and S.Hammerschmidt. 2004. Ectodomains 3 and 4 of human polymeric Immunoglobulin receptor (hpIgR) mediate invasion of Streptococcus pneumoniae into the epithelium. J. Biol. Chem. 279:6296-6304.

2001

  • Holmes,A.R., R.McNab, K.W.Millsap, M.Rohde, S.Hammerschmidt, J.L.Mawdsley, and H.F.Jenkinson. 2001. The pavA gene of Streptococcus pneumoniae encodes a fibronectin-binding protein that is essential for virulence. Mol. Microbiol. 41:1395-1408.
  • Bergmann,S., M.Rohde, G.S.Chhatwal, and S.Hammerschmidt. 2001. alpha-Enolase of Streptococcus pneumoniae is a plasmin(ogen)-binding protein displayed on the bacterial cell surface. Mol. Microbiol. 40:1273-1287.

2000

  • Hammerschmidt,S., M.P.Tillig, S.Wolff, J.P.Vaerman, and G.S.Chhatwal. 2000. Species-specific binding of human secretory component to SpsA protein of Streptococcus pneumoniae via a hexapeptide motif. Mol. Microbiol. 36:726-736.

1999

  • Hammerschmidt,S., G.Bethe, P.H.Remane, and G.S.Chhatwal. 1999. Identification of pneumococcal surface protein A as a lactoferrin-binding protein of Streptococcus pneumoniae. Infect. Immun. 67:1683-1687.

1997

  • Hammerschmidt,S., S.R.Talay, P.Brandtzaeg, and G.S.Chhatwal. 1997. SpsA, a novel pneumococcal surface protein with specific binding to secretory immunoglobulin A and secretory component. Mol. Microbiol. 25:1113-1124.
  • Heyderman,R.S., N.J.Klein, O.A.Daramola, S.Hammerschmidt, M.Frosch, B.D.Robertson, M.Levin, and C.A.Ison. 1997. Induction of human endothelial tissue factor expression by Neisseria meningitidis: the influence of bacterial killing and adherence to the endothelium. Microb. Pathog. 22:265-274. IF 2.30

1996

  • Vogel,U., S.Hammerschmidt, and M.Frosch. 1996. Sialic acids of both the capsule and the sialylated lipooligosaccharide of Neisseria meningitidis serogroup B are prerequisites for virulence of meningococci in the infant rat. Med. Microbiol. Immunol. 185:81-87.
  • Hammerschmidt,S., A.Muller, H.Sillmann, M.Muhlenhoff, R.Borrow, A.Fox, P.J.van, W.D.Zollinger, R.Gerardy-Schahn, and M.Frosch. 1996. Capsule phase variation in Neisseria meningitidis serogroup B by slipped-strand mispairing in the polysialyltransferase gene (siaD): correlation with bacterial invasion and the outbreak of meningococcal disease. Mol. Microbiol. 20:1211-1220.
  • Petering,H., S.Hammerschmidt, M.Frosch, J.P.van Putten, C.A.Ison, and B.D.Robertson. 1996. Genes associated with meningococcal capsule complex are also found in Neisseria gonorrhoeae. J. Bacteriol. 178:3342-3345.
  • Hilse,R., S.Hammerschmidt, W.Bautsch, and M.Frosch. 1996. Site-specific insertion of IS1301 and distribution in Neisseria meningitidis strains. J. Bacteriol. 178:2527-2532.
  • Hammerschmidt,S., R.Hilse, J.P.van Putten, R.Gerardy-Schahn, A.Unkmeir, and M.Frosch. 1996. Modulation of cell surface sialic acid expression in Neisseria meningitidis via a transposable genetic element. EMBO J. 15:192-198.
  • Klein,N.J., C.A.Ison, M.Peakman, M.Levin, S.Hammerschmidt, M.Frosch, and R.S.Heyderman. 1996. The influence of capsulation and lipooligosaccharide structure on neutrophil adhesion molecule expression and endothelial injury by Neisseria meningitidis. J. Infect. Dis. 173:172-179.

1994

  • Edwards,U., A.Muller, S.Hammerschmidt, R.Gerardy-Schahn, and M.Frosch. 1994. Molecular analysis of the biosynthesis pathway of the alpha-2,8 polysialic acid capsule by Neisseria meningitidis serogroup B. Mol. Microbiol. 14:141-149.
  • Hammerschmidt,S., C.Birkholz, U.Zahringer, B.D.Robertson, P.J.van, O.Ebeling, and M.Frosch. 1994. Contribution of genes from the capsule gene complex (cps) to lipooligosaccharide biosynthesis and serum resistance in Neisseria meningitidis. Mol. Microbiol. 11:885-896.

Reviews

  • Binsker, U., T.P. Kohler, and S. Hammerschmidt. 2019. Contribution of Human Thrombospondin-1 to the Pathogenesis of Gram-Positive Bacteria. J Innate Immun 11:303-315. (Review)
  • Gomez-Mejia, A., G. Gamez, and S. Hammerschmidt. 2018. Streptococcus pneumoniae two-component regulatory systems: The interplay of the pneumococcus with its environment. International journal of medical microbiology : IJMM 308:722-737.
  • Siemens N, Oehmcke-Hecht S, Mettenleiter TC, Kreikemeyer B, Valentin-Weigand P, Hammerschmidt S (2017) Port d'Entrée for Respiratory Infections - Does the Influenza A Virus Pave the Way for Bacteria? Front Microbiol. 2017 Dec 21;8:2602. doi: 10.3389/fmicb.2017.02602. eCollection 2017. Review PMID: 29312268
  • Hammerschmidt S. (2016) Special Issue on 'Microbe-host interactions'. FEBS Letters 590(21):3703-3704. doi: 10.1002/1873-3468.12466. PMID: 27869995
  • Kohler S, Voß F, Gómez Mejia A, Brown JS, Hammerschmidt S (2016) Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasion. FEBS Letters 590(21):3820-3839. doi: 10.1002/1873-3468.12352. Review. PMID: 27508940
  • Schulz, C., and S. Hammerschmidt (2013) Exploitation of physiology and metabolomics to identify pneumococcal vaccine candidates. Expert Rev Vaccine 12(9): 1033-1045.
  • Voss, S., G. Gamez, and S. Hammerschmidt (2012) Impact of pneumococcal microbial surface components recognizing adhesive matrix molecules on colonization. Mol Oral Microbiol 27:246-256. PMID: 22759310
  • Gámez, G., and S. Hammerschmidt (2012) Combat pneumococcal infections: adhesins as candidates for protein-based vaccine development. Curr Drug Targets Curr Drug Target 13(3):323-337. PMID: 22206255
  • Kreikemeyer, B., G. Gamez, I. Margarit, J.C. Giard, S. Hammerschmidt, A. Hartke, and A. Podbielski. 2010. Genomic organization, structure, regulation and pathogenic role of pilus constituents in major pathogenic Streptococci and Enterococci. Int J Med Microbiol 301(3):240-51.
  • Zipfel, P.F., T. Hallström, S. Hammerschmidt, and P.F. Zipfel (2008) The complement fitness factor H: Role in human diseases and for immune escape of pathogens, like pneumococci. Vaccine 26S: 167-174.
  • Bergmann,S. and S.Hammerschmidt. 2007. Fibrinolysis and host response in bacterial infections. Thromb. Haemost. 98:512-520.
  • Hammerschmidt,S. 2006. Adherence molecules of pathogenic pneumococci. Curr. Opin. Microbiol. 9:12-20.
  • Bergmann,S. and S.Hammerschmidt. 2006. Versatility of pneumococcal surface proteins. Microbiology 152:295-303.
  • Hammerschmidt,S., J.Hacker, and H.D.Klenk. 2005. Threat of infection: microbes of high pathogenic potential--strategies for detection, control and eradication. Int. J. Med. Microbiol. 295:141-151.

Book Chapter

  • Bergmann S, Agarwal V, Hammerschmidt S. Exploitation of host signal transduction pathways induced by Streptococcus pneumoniae. In: Brown J (Hrsg.), Hammerschmidt S (Hrsg.), Orihuela C (Hrsg.). Streptococcus pneumoniae: Molecular mechanisms of host-pathogen interactions. London: Elsevier; 2015. p. 347-362.
  • Hilleringmann M, Kohler S, Gamez de Armas G, Hammerschmidt S. Pneumococcal pili and adhesins. In: Brown J (Hrsg.), Hammerschmidt S (Hrsg.), Orihuela C (Hrsg.). Streptococcus pneumoniae: Molecular mechanisms of host-pathogen interactions. London: Elsevier; 2015. p. 309-346.
  • Weber, C., Herwald, H. and Hammerschmidt, S. (2012) Bacterial abuse of mammalian extracellular proteases during tissue invasion and infection. In: Matrix Proteases in Health and Disease (eds. Niels Behrendt), pp. 157-180. WILEY, UK. ISBN: 978-3-527-32991-5.
  • Hammerschmidt, S., and Koedel, U. (2009) Pathogenese und Pathophysiologie der akuten bakteriellen Meningitis. In: Akute bakterielle Meningitis (eds. U. Vogel and M. Frosch), pp. 30-51, UNI-MED Verlag AG, Bremen.
  • Hammerschmidt, S. and Schoen, C. (2009) Genomforschung an bakteriellen Meningitiserregern. In: Akute bakterielle Meningitis (eds. U. Vogel and M. Frosch), pp. 88-95, UNI-MED Verlag AG, Bremen.
  • Hammerschmidt, S. (2009) Surface-adherence molecules of Streptococcus pneumoniae. In: Methods in Molecular Biology, Host-Pathogen Interactions. S.Rupp and K. Sohn (eds.), Humana Press Inc., Methods Mol. Biol. 470: 29-45.
  • Bergmann, S., and Hammerschmidt, S. (2008) Fibrinolysis and host response in bacterial infections. In: Progress and Challenges in Transfusion Medicine, Hemostasis and Hemotherapy. Scharf RE (ed):, .pp.71-88 Karger, Freiburg i. Br., Germany.
  • Hammerschmidt, S. (2007) Pneumococcal virulence factors and adhesion proteins targeting the host. In: Molecular Biology of Streptococci. R.Hakenbeck and G.S.Chhatwal.(eds.), pp141-203, Horizon Bioscience, Norfolk, U.K..
  • Hammerschmidt, S. (2007) Approaches to elucidate pneumococci-host interactions. In: Molecular Biology of Streptococci. R.Hakenbeck and G.S.Chhatwal.(eds.) pp543-545, Horizon Bioscience, Norfolk, U.K..
  • Hammerschmidt, S.*, G. K. Paterson, S. Bergmann, and T. J. Mitchell (2007) Pathogenesis of Streptococcus pneumoniae infections: adaptive immunity, innate immunity, cell biology, virulence factors. In: Birkhäuser Advances in Infectious Diseases: Community acquired Pneumonia. N.Suttorp/ R.Marre (eds), pp. 139-181, Birkhäuser Verlag, Basel, Schweiz.
  • Pfister, H.-W., Koedel, U., Hammerschmidt, S., Frosch, M. (2003) Pathogenese und Pathophysiologie der akuten bakteriellen Meningitis. In: Akute bakterielle Meningitis (ed. M. Frosch), pp. 30-47, UNI-MED Verlag AG, Bremen.
  • Frosch, M., Hammerschmidt, S. (2003) Genomforschung an bakteriellen Meningitiserregern. In: Akute bakterielle Meningitis (ed. M. Frosch), pp. 84-91, UNI-MED Verlag AG, Bremen.

Books

  • Brown J (Hrsg.), Hammerschmidt S (Hrsg.), Orihuela C (Hrsg.).Streptococcus pneumoniae: Molecular mechanisms of host-pathogen interactions.ELSEVIER, Amsterdam, NL. ISBN: 978-0-12-410530-0.