Publikationen

2022

  • Lettow J, Aref R, Schüller HJ (2022) Transcriptional repressor Gal80 recruits corepressor complex Cyc8-Tup1 to structural genes of the Saccharomyces cerevisiae GAL regulon. Curr Genet (im Druck)

2021

  • Aref R, Sanad MNME, Schüller HJ (2021) Forkhead transcription factor Fkh1: insights into functional regulatory domains crucial for recruitment of Sin3 histone deacetylase complex. Curr Genet 67:487-499.
  • Olzhausen J, Grigat M, Seifert L, Ulbricht T, Schüller HJ (2021) Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene and engineering of the coenzyme A biosynthetic pathway. Appl Microbiol Biotechnol 105:7321-7337.

2020

  • Aref R, Schüller HJ (2020) Functional analysis of Cti6 core domain responsible for recruitment of epigenetic regulators Sin3, Cyc8 and Tup1. Curr Genet 66:1191-1203.

2018

  • Iuso A, Wiersma M, Schüller HJ, Pode-Shakked B, Marek-Yagel D, Grigat M, Schwarzmayr T, Berutti R, Alhaddad B, Kanon B, Grzeschik NA, Okun JG, Perles Z, Salem Y, Barel O, Vardi A, Rubinshtein M, Tirosh T, Dubnov-Raz G, Messias AC, Terrile C, Barshack I, Volkov A, Avivi C, Eyal E, Mastantuono E, Kumbar M, Abudi S, Braunisch M, Strom TM, Meitinger T, Hoffmann GF, Prokisch H, Haack TB, Brundel BJJM, Haas D, Sibon OCM, Anikster Y (2018) Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy. Am J Hum Genet 102:1018-1030.

2017

  • Kliewe, F.; Kumme, J.; Grigat, M.; Hintze, S. and Schüller, H.-J.: Opi1 mediates repression of phospholipid biosynthesis by phosphate limitation in the yeast Saccharomyces cerevisiae. Yeast 34 (2017) 67-81.
  • Kliewe, F.; Engelhardt, M.; Aref, R. and Schüller, H.-J.: Promoter recruitment of corepressors Sin3 and Cyc8 by activator proteins of the yeast Saccharomyces cerevisiae. Curr Genet 63 (2017) 739-750.
  • Hintze, S.; Engelhardt, M.; van Diepen, L.; Witt, E. and Schüller, H.-J.: Multiple Taf subunits of TFIID interact with Ino2 activation domains and contribute to expression of genes required for yeast phospholipid biosynthesis. Mol Microbiol 106 (2017) 876-890.

2013

  • Olzhausen, J.; Moritz, T.; Neetz, T. and Schüller, H.-J.: Molecular characterization of the heteromeric coenzyme A-synthesizing protein complex (CoA-SPC) in the yeast Saccharomyces cerevisiae. FEMS Yeast Res 13 (2013) 565-573.

2012

  • Grigat, M.; Jäschke, Y.; Kliewe, F.; Pfeifer, M.; Walz, S. and Schüller, H.-J.: Multiple histone deacetylases are recruited by corepressor Sin3 and contribute to gene repression mediated by Opi1 regulator of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae. Mol Genet Genomics 287 (2012) 461-472.

2011

  • Jäschke, Y.; Schwarz, J.; Clausnitzer, D.; Müller, C. and Schüller, H.-J.: Pleiotropic corepressors Sin3 and Ssn6 interact with repressor Opi1 and negatively regulate transcription of genes required for phospholipid biosynthesis in the yeast Saccharomyces cerevisiae. Mol Genet Genomics 285 (2011) 91-100.

2010

  • Dettmann, A.; Jäschke, Y.; Triebel, I.; Bogs, J.; Schröder, I. and Schüller, H.-J.: Mediator subunits and histone methyltransferase Set2 contribute to Ino2-dependent transcriptional activation of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae. Mol Genet Genomics 283 (2010) 211-221.

2009

  • Olzhausen, J.; Schübbe, S. and Schüller, H.-J.: Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: Identification of a conditional mutation in the pantothenate kinase gene CAB1. Curr Genet 55 (2009) 163-173.

2008

  • Kumme, J.; Dietz, M.; Wagner, C. and Schüller, H.-J.: Dimerization of yeast transcription factors Ino2 and Ino4 is regulated by precursors of phospholipid biosynthesis mediated by Opi1 repressor. Curr Genet 54 (2008) 35-45.

2007

  • Hoppen, J.; Dietz, M.; Warsow, G.; Rohde, R. and Schüller, H.-J.: Ribosomal protein genes in the yeast Candida albicans may be activated by a heterodimeric transcription factor related to Ino2 and Ino4 from S. cerevisiae. Mol Genet Genomics 278 (2007) 317-330.

2005

  • Hoppen, J.; Repenning, A.; Albrecht, A.; Geburtig, S. and Schüller, H.-J.: Comparative analysis of promoter regions containing binding sites of the heterodimeric transcription factor Ino2/Ino4 involved in yeast phospholipid biosynthesis. Yeast 22 (2005) 601-613.
  • Heyken, W.-T.; Repenning, A.; Kumme, J. and Schüller, H.-J.: Constitutive expression of yeast phospholipid biosynthetic genes by variants of Ino2 activator defective for interaction with Opi1 repressor. Mol. Microbiol. 56 (2005) 696-707.

2004

  • Roth, S.; Kumme, J. and Schüller, H.-J.: Transcriptional activators Cat8 and Sip4 discriminate between sequence variants of the carbon source-responsive promoter element in the yeast Saccharomyces cerevisiae. Curr. Genet. 45 (2004) 121-128.

2003

  • Schüller, H.-J.: Transcriptional control of nonfermentative metabolism in the yeast Saccharo¬myces cerevisiae. Curr. Genet. 43 (2003) 139-160.
  • Dietz, M.; Heyken, W.-T.; Hoppen, J.; Geburtig, S. and Schüller, H.-J.: TFIIB and subunits of the SAGA complex are involved in transcriptional activation of phospholipid biosynthetic genes by the regulatory protein Ino2 in the yeast Saccharomyces cerevisiae. Mol. Microbiol. 48 (2003) 1119-1130.
  • Heyken, W.-T.; Wagner, C.; Wittmann, J.; Albrecht, A. and Schüller, H.-J.: Negative regulation of phospholipid biosynthesis in Saccharomyces cerevisiae by a Candida albicans orthologue of OPI1. Yeast 20 (2003) 1177-1188.

2002

  • Schüller, H.-J.: Carbon source-dependent regulation of gene expression in the yeast Saccharomyces cerevisiae. Recent Res. Devel. Mol. Microbiol. 1 (2002) 175-209

2001

  • Wenz, P.; Schwank, S.; Hoja, U. and Schüller, H.-J.: A downstream regulatory element located within the coding sequence mediates autoregulated expression of the yeast fatty acid synthase gene FAS2 by the FAS1 gene product. Nucleic Acids Res. 29 (2001) 4625-4632.
  • Schüller, H.-J.: Phospholipid-Biosynthese in Hefe: Gensteuerung durch extrazelluläre Vorstufen. BIOforum 10 (2001) 743-744.
  • Walther, K. and Schüller, H.-J.: Adr1 and Cat8 synergistically activate the glucose-regulated alcohol dehydrogenase gene ADH2 of the yeast Saccharomyces cerevisiae. Microbiology 147 (2001) 2037-2044.
  • Wagner, C.; Dietz, M.; Wittmann, J.; Albrecht, A. and Schüller, H.-J.: The negative regulator Opi1 of phospholipid biosynthesis in yeast contacts the pleiotropic repressor Sin3 and the transcriptional activator Ino2. Mol. Microbiol. 41 (2001) 155-166.
  • Hiesinger, M.; Roth, S.; Meissner, E. and Schüller, H.-J.: Contribution of Cat8 and Sip4 to the transcriptional activation of yeast gluconeogenic genes by carbon source-responsive elements. Curr. Genet. 39 (2001) 68-76.
  • Roth, S. and Schüller, H.-J.: Cat8 and Sip4 mediate regulated transcriptional activation of the yeast malate dehydrogenase gene MDH2 by three carbon source-responsive promoter elements. Yeast 18 (2001) 151-162.

1999

  • Rahner, A.; Hiesinger, M. and Schüller, H.-J.: Deregulation of gluconeogenic structural genes by variants of the transcriptional activator Cat8p of the yeast Saccharomyces cerevisiae. Mol. Microbiol. 34 (1999) 146-156.
  • Wagner, C.; Blank, M.; Strohmann, B. and Schüller, H.-J.: Overproduction of the Opi1 repressor inhibits transcriptional activation of structural genes required for phospholipid biosynthesis in the yeast Saccharomyces cerevisiae. Yeast 15 (1999) 843-854.
  • Daum, G.; Tuller, G.; Nemec, T.; Hrastnik, C.; Balliano, G.; Cattel, L.; Milla, P.; Rocco, F.; Conzelmann, A.; Vionnet, C.; Kelly, D. E.; Kelly, S.; Schweizer, E.; Schüller, H.-J., Hojad, U.; Greiner, E. und Finger, K.: Systematic analysis of yeast strains with possible defects in lipid metabolism. Yeast 15 (1999) 601-614.
  • Ebbert, R.; Birkmann, A. and Schüller, H.-J.: The product of the SNF2/SWI2 paralogue INO80 of Saccharomyces cerevisiae required for efficient expression of various yeast structural genes is part of a high-molecular weight protein complex. Mol. Microbiol. 32 (1999) 741-751.

1997

  • Kratzer, S. and Schüller, H.-J.: Transcriptional control of the yeast acetyl-CoA synthetase gene, ACS1, by the positive regulators CAT8 and ADR1 and the pleiotropic repressor UME6. Mol. Microbiol. 26 (1997) 631-641.
  • Caspary, F.; Hartig, A. and Schüller, H.-J.: Constitutive and carbon source-responsive promoter elements are involved in the regulated expression of the Saccharomyces cerevisiae malate synthase gene MLS1. Mol. Gen. Genet. 255 (1997) 619-627.
  • Schwank, S.; Hoffmann, B. and Schüller, H.-J.: Influence of gene dosage and autoregulation of the regulatory genes INO2 and INO4 on inositol/choline-repressible gene transcription in the yeast Saccharomyces cerevisiae. Curr. Genet. 31 (1997) 462-468.
  • Entian, K.-D. and Schüller, H.-J.: Genetics of di- and trisaccharide utilization. in: Yeast Sugar Metabolism - Biochemistry, Genetics, Biotechnology, and Applications (F. K. Zimmermann, K.-D. Entian, eds.) Technomic Publ. Co., Inc.; Lancaster - Basel (1997) 225-233.
  • Entian, K.-D. and Schüller, H.-J.: Glucose repression (carbon catabolite repression) in yeast. in: Yeast Sugar Metabolism - Biochemistry, Genetics, Biotechnology, and Applications (F. K. Zimmermann, K.-D. Entian, eds.) Technomic Publ. Co., Inc.; Lancaster - Basel (1997) 409-434.

1996

  • Rahner, A.; Schöler, A.; Martens, E.; Gollwitzer, B. and Schüller, H.-J.: Dual influence of the yeast Cat1p (Snf1p) protein kinase on carbon source-dependent transcriptional activation of gluconeogenic genes by the regulatory gene CAT8. Nucleic Acids Res. 24 (1996) 2331-2337.

1995

  • Kratzer, S. and Schüller, H.-J.: Carbon source-dependent regulation of the acetyl-coenzyme A synthetase-encoding gene ACS1 from Saccharomyces cerevisiae. Gene 161 (1995) 75-79.
  • Schüller, H.-J.; Richter, K.; Hoffmann, B.; Ebbert, R. and Schweizer, E.: DNA binding site of the yeast heteromeric Ino2p/Ino4p basic helix-loop-helix transcription factor: structural requirements as defined by saturation mutagenesis. FEBS Lett. 370 (1995) 149-152.
  • Schwank, S.; Ebbert, R.; Rautenstrauß, K.; Schweizer, E. and Schüller, H.-J.: Yeast transcriptional activator INO2 interacts as an Ino2p/Ino4p basic helix-loop-helix heteromeric complex with the inositol/choline-responsive element necessary for expression of phospholipid biosynthetic genes in Saccharomyces cerevisiae. Nucleic Acids Res. 23 (1995) 230-237.

1994

  • Schüller, H.-J.; Schütz, A.; Knab, S.; Hoffmann, B. and Schweizer, E.: Importance of general regulatory factors Rap1p, Abf1p and Reb1p for the activation of yeast fatty acid synthase genes FAS1 and FAS2. Eur. J. Biochem. 225 (1994) 213-222.
  • Schöler, A. and Schüller, H.-J.: A carbon source-responsive promoter element necessary for activation of the isocitrate lyase gene ICL1 is common to genes of the gluconeogenic pathway in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 14 (1994) 3613-3622.

1993

  • Harrer, R.; Schwank, S.; Schüller, H.-J. and Schweizer, E.: Molecular cloning and analysis of the nuclear gene MRP-L6 coding for a putative mitochondrial ribosomal protein from Saccharomyces cerevisiae. Curr. Genet. 24 (1993) 136-140.
  • Egner, R.; Thumm, M.; Straub, M.; Simeon, A.; Schüller, H.-J. and Wolf, D. H.: Tracing intracellular proteolytic pathways: Proteolysis of fatty acid synthase and other cytoplasmic proteins in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 268 (1993) 27269-27276
  • Schöler, A. and Schüller, H.-J.: Structure and regulation of the isocitrate lyase gene ICL1 from the yeast Saccharomyces cerevisiae. Curr. Genet. 23 (1993) 375-381.

1992

  • Schüller, H.-J.; Schorr, R.; Hoffmann, B. and Schweizer, E.: Regulatory gene INO4 of yeast phospholipid biosynthesis is positively autoregulated and functions as a trans-activator of fatty acid synthase genes FAS1 and FAS2 from Saccharomyces cerevisiae. Nucleic Acids Res. 20 (1992) 5955-5961.
  • Niederacher, D.; Schüller, H.-J.; Grzesitza, D.; Gütlich, H.; Hauser, H.-P.; Wagner, T. and Entian, K.-D.: Identification of UAS elements and binding proteins necessary for derepression of Saccharomyces cerevisiae fructose-1,6-bisphosphatase. Curr. Genet. 22 (1992) 363-370.
  • Schüller, H.-J.; Hahn, A.; Tröster, F.; Schütz, A. and Schweizer, E.: Coordinate genetic control of yeast fatty acid synthase genes FAS1 and FAS2 by an upstream activation site common to genes involved in membrane lipid biosynthesis. EMBO J. 11 (1992) 107-114.
  • Schüller, H.-J.; Förtsch, B.; Rautenstrauß, B.; Wolf, D. H. and Schweizer, E.: Differential proteolytic sensitivity of yeast fatty acid synthetase subunits alpha and beta contributing to a balanced ratio of both fatty acid synthetase components. Eur. J. Biochem. 203 (1992) 607-614.

1991

  • Schüller, H.-J. and Entian, K.-D.: Extragenic suppressors of yeast glucose derepression mutants leading to constitutive synthesis of several glucose-repressible enzymes. J. Bacteriol. 173 (1991) 2045-2052.

1988

  • Schüller, H.-J. and Entian, K.-D.: Molecular characterization of yeast regulatory gene CAT3 necessary for glucose derepression and nuclear localization of its product. Gene 67 (1988) 247-257.

1987

  • Schüller, H.-J. and Entian, K.-D: Isolation and expression analysis of two yeast regulatory genes involved in the derepression of glucose-repressible enzymes. Mol. Gen. Genet. 209 (1987) 366-373.