Dr. Ulrike Mäder

Gruppenleiterin

Interfakultäres Institut für Genetik und Funktionelle Genomforschung

Felix-Hausdorff-Straße 8

D-17475 Greifswald

 

Büro: Raum 2.60

Telefon +49 3834 420 5813

Telefax +49 3834 420 5890

ulrike.maederuni-greifswaldde

Forschungsinteressen

  • Transkriptionsregulation in Gram-positiven Bakterien
  • Regulatorische RNAs
  • Web-Tools für die funktionelle Genomannotation
Publikationen
2024
Galindez G, List M, Baumbach J, Völker U, Mäder U, Blumenthal DB, Kacprowski T (2024) Inference of differential gene regulatory networks using boosted differential trees. Bioinform Adv. 4:vbae034.
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Ganske A, Busch LM, Hentschker C, Reder A, Michalik S, Surmann K, Völker U, Mäder U (2024) Exploring the targetome of IsrR, an iron-regulated sRNA controlling the synthesis of iron-containing proteins in Staphylococcus aureus. Front Microbiol. 15:1439352.
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Harms M, Michalik S, Hildebrandt P, Schaffer M, Gesell Salazar M, Gerth U, Mäder U, van Dijl JM, Hecker M, Völker U, Reder A (2024) Activation of the general stress response sigma factor SigB prevents competence development in Bacillus subtilis. mBio.
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Li X, Busch LM, Piersma S, Wang M, Liu L, Gesell Salazar M, Surmann K, Mäder U, Völker U, Buist G, van Dijl JM (2024) Functional and Proteomic Dissection of the Contributions of CodY, SigB and the Hibernation Promoting Factor HPF to Interactions of Staphylococcus aureus USA300 with Human Lung Epithelial Cells. J Proteome Res. 23:4742-4760.
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2023
Öktem A, Núñez-Nepomuceno D, Ferrero-Bordera B, Walgraeve J, Seefried M, Gesell Salazar M, Steil L, Michalik S, Maaß S, Becher D, Mäder U, Völker U, van Dijl JM (2023) Enhancing bacterial fitness and recombinant enzyme yield by engineering the quality control protease HtrA of Bacillus subtilis. Microbiol Spectr. 0:e0177823.
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2021
Bunk B, Jakóbczak B, Florian V, Dittmar D, Mäder U, Jarek M, Häußler S, Baums CG, Völker U, Michalik S (2021) Complete Genome Sequences of Streptococcus suis Pig-Pathogenic Strains 10, 13-00283-02, and 16085/3b. Microbiol resour announc. 10:1-3.
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Dérozier S, Nicolas P, Mäder U, Guérin C (2021) Genoscapist: online exploration of quantitative profiles along genomes via interactively customized graphical representations. Bioinformatics.
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Faßhauer P, Busche T, Kalinowski J, Mäder U, Poehlein A, Daniel R, Stülke J (2021) Functional Redundancy and Specialization of the Conserved Cold Shock Proteins in Bacillus subtilis. Microorganisms. 9:1434.
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Hirschmann S, Gómez-Mejia A, Mäder U, Karsunke J, Driesch D, Rohde M, Häussler S, Burchhardt G, Hammerschmidt S (2021) The Two-Component System 09 Regulates Pneumococcal Carbohydrate Metabolism and Capsule Expression. Microorganisms. 9:468.
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Krüger L, Herzberg C, Rath H, Pedreira T, Ischebeck T, Poehlein A, Gundlach J, Daniel R, Völker U, Mäder U, Stülke J (2021) Essentiality of c-di-AMP in Bacillus subtilis: Bypassing mutations converge in potassium and glutamate homeostasis. PLOS Genet. 17:e1009092.
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Michalik S, Reder A, Richts B, Faßhauer P, Mäder U, Pedreira T, Poehlein A, van Heel AJ, van Tilburg AY, Altenbuchner J, Klewing A, Reuß DR, Daniel R, Commichau FM, Kuipers OP, Hamoen LW, Völker U, Stülke J (2021) The Bacillus subtilis Minimal Genome Compendium. ACS Synth Biol.
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Prajapati B, Bernal-Cabas M, López-Álvarez M, Schaffer M, Bartel J, Rath H, Steil L, Becher D, Völker U, Mäder U, van Dijl JM (2021) Double trouble: Bacillus depends on a functional Tat machinery to avoid severe oxidative stress and starvation upon entry into a NaCl-depleted environment. Biochim Biophys Acta Mol Cell Res. 1868:118914.
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2020
Boonstra M, Schaffer M, Sousa J, Morawska L, Holsappel S, Hildebrandt P, Sappa PK, Rath H, de Jong A, Lalk M, Mäder U, Völker U, Kuipers OP (2020) Analyses of competent and non-competent subpopulations of Bacillus subtilis reveal yhfW, yhxC and ncRNAs as novel players in competence. Environ Microbiol. 00.
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Horvatek P, Salzer A, Hanna AMF, Gratani FL, Keinhörster D, Korn N, Borisova M, Mayer C, Rejman D, Mäder U, Wolz C (2020) Inducible expression of (pp)pGpp synthetases in Staphylococcus aureus is associated with activation of stress response genes. PLOS Genet. 16:e1009282.
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Rath H, Sappa PK, Hoffmann T, Salazar MG, Reder A, Steil L, Hecker M, Bremer E, Mäder U, Völker U (2020) Impact of high salinity and the compatible solute glycine betaine on gene expression of Bacillus subtilis. Environ Microbiol.
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Rath H, Reder A, Hoffmann T, Hammer E, Seubert A, Bremer E, Völker U, Mäder U (2020) Management of Osmoprotectant Uptake Hierarchy in Bacillus subtilis via a SigB-Dependent Antisense RNA. Front Microbiol. 11:622.
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2019
Chi BK, Huyen NTT, Loi VV, Gruhlke MCH, Schaffer M, Mäder U, Maaß S, Becher D, Bernhardt J, Arbach M, Hamilton CJ, Slusarenko AJ, Antelmann H (2019) The Disulfide Stress Response and Protein S-thioallylation Caused by Allicin and Diallyl Polysulfanes in Bacillus subtilis as Revealed by Transcriptomics and Proteomics. Antioxidants (Basel). 8:605.
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Nguyen M, Saising J, Tribelli PM, Nega M, Diene SM, François P, Schrenzel J, Spröer C, Bunk B, Ebner P, Hertlein T, Kumari N, Härtner T, Wistuba D, Voravuthikunchai SP, Mäder U, Ohlsen K, Götz F (2019) Inactivation of farR Causes High Rhodomyrtone Resistance and Increased Pathogenicity in Staphylococcus aureus. Front Microbiol. 10:1157.
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2018
Fuchs S, Mehlan H, Bernhardt J, Hennig A, Michalik S, Surmann K, Pané-Farré J, Giese A, Weiss S, Backert L, Herbig A, Nieselt K, Hecker M, Völker U, Mäder U (2018) AureoWiki ̵ The repository of the Staphylococcus aureus research and annotation community. Int J Med Microbiol. 308:558-568.
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Gómez-Mejia A, Gámez G, Hirschmann S, Kluger V, Rath H, Böhm S, Voss F, Kakar N, Petruschka L, Völker U, Brückner R, Mäder U, Hammerschmidt S (2018) Pneumococcal Metabolic Adaptation and Colonization Are Regulated by the Two-Component Regulatory System 08. mSphere. 3:e00165-18.
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Hecker M, Mäder U, Völker U (2018) From the genome sequence via the proteome to cell physiology - Pathoproteomics and pathophysiology of Staphylococcus aureus. Int J Med Microbiol.
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Nagel A, Michalik S, Debarbouille M, Hertlein T, Gesell Salazar M, Rath H, Msadek T, Ohlsen K, van Dijl JM, Völker U, Mäder U (2018) Inhibition of Rho Activity Increases Expression of SaeRS-Dependent Virulence Factor Genes in Staphylococcus aureus, Showing a Link between Transcription Termination, Antibiotic Action, and Virulence. MBio. 9:1-17.
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Reuß DR, Rath H, Thürmer A, Benda M, Daniel R, Völker U, Mäder U, Commichau FM, Stülke J (2018) Changes of DNA topology affect the global transcription landscape and allow rapid growth of a Bacillus subtilis mutant lacking carbon catabolite repression. Metab Eng. 45:171-179.
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2017
Hoffmann T, Bleisteiner M, Sappa PK, Steil L, Mäder U, Völker U, Bremer E (2017) Synthesis of the compatible solute proline by : point mutations rendering the osmotically controlled proHJ promoter hyperactive. Environ Microbiol. 19:3700-3720.
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Mekonnen SA, Palma Medina LM, Glasner C, Tsompanidou E, de Jong A, Grasso S, Schaffer M, Mäder U, Larsen AR, Gumpert H, Westh H, Völker U, Otto A, Becher D, van Dijl JM (2017) Signatures of cytoplasmic proteins in the exoproteome distinguish community- and hospital-associated methicillin-resistant Staphylococcus aureus USA300 lineages. Virulence. 8:891-907.
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Michalik S, Depke M, Murr A, Gesell Salazar M, Kusebauch U, Sun Z, Meyer TC, Surmann K, Pförtner H, Hildebrandt P, Weiss S, Palma Medina LM, Gutjahr M, Hammer E, Becher D, Pribyl T, Hammerschmidt S, Deutsch EW, Bader SL, Hecker M, Moritz RL, Mäder U, Völker U, Schmidt F (2017) A global Staphylococcus aureus proteome resource applied to the in vivo characterization of host-pathogen interactions. Sci Rep. 7:9718.
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Reuß DR, Altenbuchner J, Mäder U, Rath H, Ischebeck T, Sappa PK, Thürmer A, Guérin C, Nicolas P, Steil L, Zhu B, Feussner I, Klumpp S, Daniel R, Commichau FM, Völker U, Stülke J (2017) Large-scale reduction of the genome: consequences for the transcriptional network, resource allocation, and metabolism. Genome Res. 27:289-299.
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2016
Bonn F, Pané-Farré J, Schlüter R, Schaffer M, Fuchs S, Bernhardt J, Riedel K, Otto A, Völker U, van Dijl JM, Hecker M, Mäder U, Becher D (2016) Global analysis of the impact of linezolid onto virulence factor production in USA300. Int J Med Microbiol. 306:131-40.
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Borkowski O, Goelzer A, Schaffer M, Calabre M, Mäder U, Aymerich S, Jules M, Fromion V (2016) Translation elicits a growth rate-dependent, genome-wide, differential protein production in . Mol Syst Biol. 12:870.
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Gundlach J, Rath H, Herzberg C, Mäder U, Stülke J (2016) Second Messenger Signaling in : Accumulation of Cyclic di-AMP Inhibits Biofilm Formation. Front Microbiol. 7:804.
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Mäder U, Nicolas P, Depke M, Pané-Farré J, Debarbouille M, van der Kooi-Pol MM, Guérin C, Dérozier S, Hiron A, Jarmer H, Leduc A, Michalik S, Reilman E, Schaffer M, Schmidt F, Bessières P, Noirot P, Hecker M, Msadek T, Völker U, van Dijl JM (2016) Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions. PLOS Genet. 12:e1005962.
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Michna RH, Zhu B, Mäder U, Stülke J (2016) SubtiWiki 2.0--an integrated database for the model organism . Nucleic Acids Res. 44:D654-62.
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Vu CH, Kolata J, Stentzel S, Beyer A, Gesell Salazar M, Steil L, Pané-Farré J, Rühmling V, Engelmann S, Götz F, van Dijl JM, Hecker M, Mäder U, Schmidt F, Völker U, Bröker BM (2016) Adaptive immune response to lipoproteins of Staphylococcus aureus in healthy subjects. Proteomics. 16:2667-2677.
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2015
Homuth G, Wahl S, Müller C, Schurmann C, Mäder U, Blankenberg S, Carstensen M, Dörr M, Endlich K, Englbrecht C, Felix SB, Gieger C, Grallert H, Herder C, Illig T, Kruppa J, Marzi CS, Mayerle J, Meitinger T, Metspalu A, Nauck M, Peters A, Rathmann W, Reinmaa E, Rettig R, Roden M, Schillert A, Schramm K, Steil L, Strauch K, Teumer A, Völzke H, Wallaschofski H, Wild PS, Ziegler A, Völker U, Prokisch H, Zeller T (2015) Extensive alterations of the whole-blood transcriptome are associated with body mass index: results of an mRNA profiling study involving two large population-based cohorts. BMC Med Genomics. 8:65.
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Mars RAT, Nicolas P, Ciccolini M, Reilman E, Reder A, Schaffer M, Mäder U, Völker U, van Dijl JM, Denham EL (2015) Small regulatory RNA-induced growth rate heterogeneity of . PLOS Genet. 11:e1005046.
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2014
Kohlstedt M, Sappa PK, Meyer H, Maaß S, Zaprasis A, Hoffmann T, Becker J, Steil L, Hecker M, van Dijl JM, Lalk M, Mäder U, Stülke J, Bremer E, Völker U, Wittmann C (2014) Adaptation of carbon core metabolism to simultaneous nutrient limitation and osmotic challenge: a multi-omics perspective. Environ Microbiol. 16:1898-917.
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Meyer H, Weidmann H, Mäder U, Hecker M, Völker U, Lalk M (2014) A time resolved metabolomics study: the influence of different carbon sources during growth and starvation of . Mol Biosyst. 10:1812-23.
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Müller M, Reiß S, Schlüter R, Mäder U, Beyer A, Reiß W, Marles-Wright J, Lewis RJ, Pförtner H, Völker U, Riedel K, Hecker M, Engelmann S, Pané-Farré J (2014) Deletion of membrane-associated Asp23 leads to upregulation of cell wall stress genes in Staphylococcus aureus. Mol Microbiol. 93:1259-68.
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Muntel J, Fromion V, Goelzer A, Maa$\beta$ S, Mäder U, Büttner K, Hecker M, Becher D (2014) Comprehensive absolute quantification of the cytosolic proteome of by data independent, parallel fragmentation in liquid chromatography/mass spectrometry (LC/MS(E)). Mol Cell Proteomics. 13:1008-19.
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Schulz C, Gierok P, Petruschka L, Lalk M, Mäder U, Hammerschmidt S (2014) Regulation of the arginine deiminase system by ArgR2 interferes with arginine metabolism and fitness of Streptococcus pneumoniae. MBio. 5:e01858-14.
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2013
Winter T, Bernhardt J, Winter J, Mäder U, Schlüter R, Weltmann K, Hecker M, Kusch H (2013) Common versus noble differentially responds to air and argon gas plasma. Proteomics. 13:2608-21.
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2012
Buescher JM, Liebermeister W, Jules M, Uhr M, Muntel J, Botella E, Hessling B, Kleijn RJ, Le Chat L, Lecointe F, Mäder U, Nicolas P, Piersma S, Rügheimer F, Becher D, Bessieres P, Bidnenko E, Denham EL, Dervyn E, Devine KM, Doherty G, Drulhe S, Felicori L, Fogg MJ, Goelzer A, Hansen A, Harwood CR, Hecker M, Hubner S, Hultschig C, Jarmer H, Klipp E, Leduc A, Lewis P, Molina F, Noirot P, Peres S, Pigeonneau N, Pohl S, Rasmussen S, Rinn B, Schaffer M, Schnidder J, Schwikowski B, Van Dijl JM, Veiga P, Walsh S, Wilkinson AJ, Stelling J, Aymerich S, Sauer U (2012) Global network reorganization during dynamic adaptations of metabolism. Science. 335:1099-103.
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Delauné A, Dubrac S, Blanchet C, Poupel O, Mäder U, Hiron A, Leduc A, Fitting C, Nicolas P, Cavaillon J, Adib-Conquy M, Msadek T (2012) The WalKR system controls major staphylococcal virulence genes and is involved in triggering the host inflammatory response. Infect Immun. 80:3438-53.
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Elsholz AKW, Turgay K, Michalik S, Hessling B, Gronau K, Oertel D, Mäder U, Bernhardt J, Becher D, Hecker M, Gerth U (2012) Global impact of protein arginine phosphorylation on the physiology of . Proc Natl Acad Sci U S A. 109:7451-6.
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Lehnik-Habrink M, Lewis RJ, Mäder U, Stülke J (2012) RNA degradation in : an interplay of essential endo- and exoribonucleases. Mol Microbiol. 84:1005-17.
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Mäder U, Nicolas P. (2012). Array-based approaches to bacterial transcriptome analysis. In: Methods in Microbiology, Volume 39 “Systems Biology of Bacteria” (Ed.: C. Harwood C, A. Wipat), p. 151-182.
Mäder U, Schmeisky AG, Flórez LA, Stülke J (2012) SubtiWiki--a comprehensive community resource for the model organism . Nucleic Acids Res. 40:D1278-87.
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Nannapaneni P, Hertwig F, Depke M, Hecker M, Mäder U, Völker U, Steil L, van Hijum SAFT (2012) Defining the structure of the general stress regulon of using targeted microarray analysis and random forest classification. Microbiology. 158:696-707.
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Nicolas P, Mäder U, Dervyn E, Rochat T, Leduc A, Pigeonneau N, Bidnenko E, Marchadier E, Hoebeke M, Aymerich S, Becher D, Bisicchia P, Botella E, Delumeau O, Doherty G, Denham EL, Fogg MJ, Fromion V, Goelzer A, Hansen A, Härtig E, Harwood CR, Homuth G, Jarmer H, Jules M, Klipp E, Le Chat L, Lecointe F, Lewis P, Liebermeister W, March A, Mars RAT, Nannapaneni P, Noone D, Pohl S, Rinn B, Rügheimer F, Sappa PK, Samson F, Schaffer M, Schwikowski B, Steil L, Stülke J, Wiegert T, Devine KM, Wilkinson AJ, van Dijl JM, Hecker M, Völker U, Bessières P, Noirot P (2012) Condition-dependent transcriptome reveals high-level regulatory architecture in . Science. 335:1103-6.
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2011
Chi BK, Gronau K, Mäder U, Hessling B, Becher D, Antelmann H (2011) S-bacillithiolation protects against hypochlorite stress in as revealed by transcriptomics and redox proteomics. Mol Cell Proteomics. 10:M111.009506.
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Falord M, Mäder U, Hiron A, Débarbouillé M, Msadek T (2011) Investigation of the Staphylococcus aureus GraSR regulon reveals novel links to virulence, stress response and cell wall signal transduction pathways. PLoS One. 6:e21323.
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Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J (2011) RNA processing in : identification of targets of the essential RNase Y. Mol Microbiol. 81:1459-73.
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Mäder U, Nicolas P, Richard H, Bessières P, Aymerich S (2011) Comprehensive identification and quantification of microbial transcriptomes by genome-wide unbiased methods. Curr Opin Biotechnol. 22:32-41.
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Pohl S, Tu WY, Aldridge PD, Gillespie C, Hahne H, Mäder U, Read TD, Harwood CR (2011) Combined proteomic and transcriptomic analysis of the response of Bacillus anthracis to oxidative stress. Proteomics. 11:3036-55.
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Schroeter R, Voigt B, Jürgen B, Methling K, Pöther D, Schäfer H, Albrecht D, Mostertz J, Mäder U, Evers S, Maurer K, Lalk M, Mascher T, Hecker M, Schweder T (2011) The peroxide stress response of Bacillus licheniformis. Proteomics. 11:2851-66.
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van der Ploeg R, Mäder U, Homuth G, Schaffer M, Denham EL, Monteferrante CG, Miethke M, Marahiel MA, Harwood CR, Winter T, Hecker M, Antelmann H, van Dijl JM (2011) Environmental salinity determines the specificity and need for Tat-dependent secretion of the YwbN protein in . PLoS One. 6:e18140.
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Wecke T, Bauer T, Harth H, Mäder U, Mascher T (2011) The rhamnolipid stress response of . FEMS Microbiol Lett. 323:113-23.
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Winter T, Winter J, Polak M, Kusch K, Mäder U, Sietmann R, Ehlbeck J, van Hijum S, Weltmann K, Hecker M, Kusch H (2011) Characterization of the global impact of low temperature gas plasma on vegetative microorganisms. Proteomics. 11:3518-30.
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Zuber P, Chauhan S, Pilaka P, Nakano MM, Gurumoorthy S, Lin AA, Barendt SM, Chi BK, Antelmann H, Mäder U (2011) Phenotype enhancement screen of a regulatory spx mutant unveils a role for the ytpQ gene in the control of iron homeostasis. PLoS One. 6:e25066.
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2010
Gimpel M, Heidrich N, Mäder U, Krügel H, Brantl S (2010) A dual-function sRNA from B. subtilis: SR1 acts as a peptide encoding mRNA on the gapA operon. Mol Microbiol. 76:990-1009.
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Hahne H, Mäder U, Otto A, Bonn F, Steil L, Bremer E, Hecker M, Becher D (2010) A comprehensive proteomics and transcriptomics analysis of salt stress adaptation. J Bacteriol. 192:870-82.
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Lammers CR, Flórez LA, Schmeisky AG, Roppel SF, Mäder U, Hamoen L, Stülke J (2010) Connecting parts with processes: SubtiWiki and SubtiPathways integrate gene and pathway annotation for . Microbiology. 156:849-59.
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Otto A, Bernhardt J, Meyer H, Schaffer M, Herbst F, Siebourg J, Mäder U, Lalk M, Hecker M, Becher D (2010) Systems-wide temporal proteomic profiling in glucose-starved . Nat Commun. 1:137.
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Wolf D, Kalamorz F, Wecke T, Juszczak A, Mäder U, Homuth G, Jordan S, Kirstein J, Hoppert M, Voigt B, Hecker M, Mascher T (2010) In-depth profiling of the LiaR response of . J Bacteriol. 192:4680-93.
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